Publications by authors named "C J Secombe"

. Data from two-plane electrical impedance tomography (EIT) can be reconstructed into various slices of functional lung images, allowing for more complete visualisation and assessment of lung physiology in health and disease. The aim of this study was to confirm the ability of 3D EIT to visualise normal lung anatomy and physiology at rest and during increased ventilation (represented by rebreathing).

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The provision of veterinary services is essential to deliver animal health and welfare outcomes, but over the last several decades demand for veterinary services in animal production systems has broadly declined in Australia. Reduced demand is closely related to a decline in the size of the production animal veterinary workforce, and there is evidence that the percentage of veterinarians participating in the delivery of veterinary services to animal production systems has lessened. Reduced demand for veterinary services in the production animal sector is likely to be attributed to several factors, including challenges around widespread adoption of preventive veterinary services, improved self-efficacy of producers through advancement of knowledge, and potential concern by producers over the role of veterinarians in production animal systems.

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Electrical impedance tomography (EIT) is a non-invasive real-time non-ionising imaging modality that has many applications. Since the first recorded use in 1978, the technology has become more widely used especially in human adult and neonatal critical care monitoring. Recently, there has been an increase in research on thoracic EIT in veterinary medicine.

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We identified and isolated a novel Hendra virus (HeV) variant not detected by routine testing from a horse in Queensland, Australia, that died from acute illness with signs consistent with HeV infection. Using whole-genome sequencing and phylogenetic analysis, we determined the variant had ≈83% nt identity with prototypic HeV. In silico and in vitro comparisons of the receptor-binding protein with prototypic HeV support that the human monoclonal antibody m102.

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Background: Left-sided cardiac volume overload (LCVO) can cause fluid accumulation in lung tissue changing the distribution of ventilation, which can be evaluated by electrical impedance tomography (EIT).

Objectives: To describe and compare EIT variables in horses with naturally occurring compensated and decompensated LCVO and compare them to a healthy cohort.

Animals: Fourteen adult horses, including university teaching horses and clinical cases (healthy: 8; LCVO: 4 compensated, 2 decompensated).

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