Publications by authors named "C J Schuster"
Article Synopsis
- - Intrahepatic cholangiocarcinoma is a severe form of cancer that behaves differently from other biliary cancers, prompting a study on the effects of its genetic mutations on survival outcomes after surgical resection.
- - A systematic review of 24 studies revealed that mutations in the KRAS, IDH1/2, and TP53 genes significantly influenced patient survival rates, showcasing key differences in the prevalence of KRAS and IDH1/2 mutations between Western and Eastern populations.
- - Understanding these genetic mutations can inform targeted therapies in treatment plans, although rare mutations may lead to inconsistent results and biases in prognostic assessments.
Introduction: Studies directly comparing the effectiveness of different biologics over long observation periods are lacking. As many treatment guidelines are formulated based on drug class, there is a particular need to compare drug classes rather than specific biologic agents.
Methods: This post hoc analysis compares the effectiveness and durability of biologics that target the interleukin (IL)-17 A ligands or the IL-17 receptor A (IL-17RA) relative to other approved drug classes in patients with moderate-to-severe plaque psoriasis, through 12 months in a real-world setting.
Background: Head and neck squamous cell carcinomas (HNSCCs) are heterogeneous in terms of origin and aetiology. In addition, there is uncertainty about the genetic evolution from initial diagnosis to recurrence after primary treatments and further disease progression following systemic treatment. Changes in the genetic profile have implications on the selection of appropriate treatments for patients, especially in the era of targeted therapies and immunotherapies.
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- * It found that stronger beliefs in equal childcare (both in what is considered normal and what should be the case) are associated with the availability of parental leave policies.
- * While the data suggests that changes in parental leave policies can shift perceptions of social norms over time, the study acknowledges that it cannot definitively determine cause-and-effect relationships due to its cross-sectional design.
Background: Placental macrophages, Hofbauer cells (HBC) are the only fetal immune cell population within the stroma of healthy placenta along pregnancy. They are central players in maintaining immune tolerance during pregnancy. Immunometabolism emerged a few years ago as a new field that integrates cellular metabolism with immune responses, however, the immunometabolism of HBC has not been explored yet.
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