Cost-effectiveness of a domestic violence and abuse training and support programme in primary care in the real world: updated modelling based on an MRC phase IV observational pragmatic implementation study.

Objectives: To evaluate the cost-effectiveness of the implementation of the Identification and Referral to Improve Safety (IRIS) programme using up-to-date real-world information on costs and effectiveness from routine clinical practice. A Markov model was constructed to estimate mean costs and quality-adjusted life-years (QALYs) of IRIS versus usual care per woman registered at a general practice from a societal and health service perspective with a 10-year time horizon.

Design And Setting: Cost-utility analysis in UK general practices, including data from six sites which have been running IRIS for at least 2 years across England.

Absorption and tissue distribution of dietary quercetin and quercetin glycosides of apple skin in broiler chickens.

Background: Apple skins are a rich source of flavonols, in particular quercetin (Q) glycosides. The objective of the present study was to investigate the presence of Q metabolites in plasma, various tissues, and excreta when the commercial broiler chicken's diet was supplemented with Q (0, 50, 150, 300, or 600 mg kg(-1) body weight per day), an apple skin extract (ASE; 50, 150 mg total phenolics kg(-1) body weight per day), or a dried apple skin powder (ASP; 50 mg total phenolics kg(-1) body weight per day).

Results: When Q was supplemented for 3 days, Q sulfate, Q glucuronide, Q glucoside glucuronide, Q glucoside sulfate, and isorhamnetin glucoside were detected by liquid chromatography-tandem mass spectrometry in the liver and duodenum.

Determinants of consultation rate in patients with anxiety and depressive disorders in primary care.

Background: Although it is recognized that anxiety and depression are associated with frequent attendance in primary care, not all patients with these disorders attend frequently. The factors associated with general practice consultation in the important group of patients with anxiety and depressive disorders are not clear.

Objectives: Our aim was to determine prospectively the factors which predict consultation rate in a cohort of patients with anxiety and depressive disorders in primary care.

Clinical and patient satisfaction outcomes of a new treatment for somatized mental disorder taught to general practitioners.

Background: Patients with mental disorder presenting with medically unexplained symptoms (somatized mental disorder) are common in primary care, difficult to treat, and function poorly in their daily lives.

Aim: To examine the effects on patient outcome and satisfaction of a training package for somatized mental disorder delivered to general practitioners (GPs).

Method: A prospective study of a before-and-after training study of different cohorts of patients attending eight GPs who acted as their own controls.

Cost-effectiveness of a new treatment for somatized mental disorder taught to GPs.

Background: Patients with mental disorder presenting with medically unexplained symptoms (somatized mental disorder) are difficult to treat and consume a lot of health care.

Objectives: The aim of the study was to examine the cost-effectiveness of a training package for somatized mental disorder delivered by GPs.

Methods: The study design was a prospective, before- and after-training study of different cohorts of patients attending eight GPs, acting as their own controls.