Publications by authors named "C J Raport"

Article Synopsis
  • ALD403 is a monoclonal antibody designed to inhibit CGRP, showing potential as a migraine preventive treatment with a good safety profile.
  • The drug was developed by modifying rabbit antibodies to prevent unwanted immune reactions, and it effectively blocks CGRP-induced actions in lab tests.
  • ALD403 did not trigger immune cell destruction mechanisms and demonstrated strong efficacy in animal studies by reducing blood flow response linked to pain, highlighting its potential for migraine management.
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Chemokines play a key role in leukocyte recruitment during inflammation and are implicated in the pathogenesis of a number of autoimmune diseases. As such, inhibiting chemokine signaling has been of keen interest for the development of therapeutic agents. This endeavor, however, has been hampered due to complexities in the chemokine system.

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Background: Chemokines and their receptors could play key roles in the recruitment of T cells to the asthmatic lung. CCR8 is preferentially expressed on T-helper type 2 cells, and is thought to play a role in the pathogenesis of human asthma.

Objective: Determine the expression of CCR8 on T cells in blood, bronchoalveolar lavage (BAL) and bronchial mucosa from asthmatics and normal subjects.

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The chemoattractant activity of macrophage-derived chemokine (MDC), EBI1-ligand chemokine (ELC), and secondary lymphoid tissue chemokine (SLC) on human thymocytes was analyzed. Both ELC and SLC caused the accumulation of CD4+CD8- or CD4-CD8+ CD45RA+ thymocytes showing high CD3 expression. By contrast, a remarkable proportion of MDC-responsive thymocytes were CD4+CD8+ cells exhibiting reduced levels of CD8 or CD4+CD8- cells showing CD3 and CD45R0, but not CD45RA.

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