Major adverse cardiovascular, thromboembolic and malignancy events in the filgotinib rheumatoid arthritis and ulcerative colitis clinical development programmes.

Objectives: Long-term safety is fundamental for treatment decision-making. This integrated analysis of filgotinib clinical trials in rheumatoid arthritis (RA) and ulcerative colitis (UC) assessed adverse events of interest (AEI): major adverse cardiovascular events (MACE), venous thromboembolism (VTE) and malignancies.

Methods: Data were integrated from all phase II and III trials that have investigated filgotinib 100 mg or 200 mg once daily in RA and UC to date.

[Implementation and evaluation of a solution for automated documentation of the doctor-patient dialogue (ADAPI) in ophthalmology using the example of the IVI routine].

Background: The increasing bureaucratic burden in everyday clinical practice impairs doctor-patient communication (DPC). Effective use of digital technologies, such as automated semantic speech recognition (ASR) with automated extraction of diagnostically relevant information can provide a solution.

Objective: The aim was to determine the extent to which ASR in conjunction with semantic information extraction for automated documentation of the doctor-patient dialogue (ADAPI) can be integrated into everyday clinical practice using the IVI routine as an example and whether patient care can be improved through process optimization.

Isolated Sagittal Craniosynostosis and Open or Endoscopic Cranial Vault Remodeling: An Evaluation of Developmental Outcomes.

Background: Craniosynostosis, a condition involving the premature fusion of cranial sutures, can impair brain development and potentially lead to developmental delays. This study compares open cranial vault remodeling versus endoscopic strip craniectomy treatment for isolated sagittal craniosynostosis, primarily focusing on development outcomes.

Methods: A retrospective cohort study was conducted at a tertiary pediatric surgery center, involving all 45 patients treated surgically for isolated sagittal craniosynostosis from 2013 to 2024.

Dynamic and reciprocal relations between job insecurity and physical and mental health.

This article reports the results of a 33-wave longitudinal study of relations between job insecurity and physical and mental health based on monthly data collected between April 2020 and December 2022 among = 1,666 employees in Germany. We integrate dynamic theorizing from the transactional stress model and domain-specific theorizing based on stressor creation and perception to frame hypotheses regarding dynamic and reciprocal relations between job insecurity and health over time. We find that lower physical health predicted subsequent increases in job insecurity and higher physical health predicted subsequent decreases in job insecurity.