Publications by authors named "C J Possidente"
Article Synopsis
- Bipolar disorder (BD) involves changes in emotion regulation (ER) strategies, with depressive and (hypo)manic symptoms linked to using maladaptive strategies more than adaptive ones.
- A systematic review and Bayesian network meta-analysis of 15 studies identified rumination as the ER strategy most associated with both depressive (ES=0.43) and (hypo)manic symptoms (ES=0.26).
- The results highlight the significance of rumination in BD and suggest that disrupted ER is more apparent during depressive phases; however, the cross-sectional nature of the studies limits understanding of causal relationships, indicating a need for future longitudinal research.
Article Synopsis
- This review explores how antidepressants affect gut microbiota composition and function, suggesting that gut bacteria may influence how well antidepressants work.
- Antidepressant users typically show increased β-diversity and notable changes in specific gut bacteria, such as higher levels of Bacteroidetes and decreases in Firmicutes.
- The study also identifies potential biomarkers, like certain gut bacteria populations, that could predict response to antidepressant treatment, emphasizing the necessity for more research to better understand these interactions.
Article Synopsis
- This literature review examines the genetic factors influencing treatment responses in major depressive disorder (MDD), addressing previous limitations in research due to MDD's complexity.
- The study found 13 genome-wide association studies (GWASs) and one whole exome sequencing study (WES) that identified key genes and biological processes linked to treatment outcomes.
- Four specific genes were associated with both poor treatment outcomes and certain depressive symptoms, indicating potential shared biological mechanisms that could lead to personalized treatment approaches.
Background: There are no recommendations based on the efficacy of specific drugs for the treatment of psychotic depression. To address this evidence gap, we did a network meta-analysis to assess and compare the efficacy and safety of pharmacological treatments for psychotic depression.
Methods: In this systematic review and network meta-analysis, we searched ClinicalTrials.
Obsessive-compulsive disorder (OCD) frequently co-occurs with various psychiatric conditions and may impact as many as one-fifth of individuals diagnosed with bipolar disorder (BD). Despite the expanding body of literature on the coexistence of OCD and BD, there is a notable lack of comprehensive data pertaining to the distinct features of obsessive-compulsive symptoms that define this comorbidity. To bridge this knowledge gap, we conducted a systematic search of PubMed/MEDLINE, Scopus, EMBASE, and PsycINFO until August 7th, 2023.
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