Publications by authors named "C J Michaud"
Signal transduction downstream of axon guidance molecules is essential to steer developing axons. Second messengers including cAMP are key molecules shared by a multitude of signaling pathways and are required for a wide range of cellular processes including axon pathfinding. Yet, how these signaling molecules achieve specificity for each of their downstream pathways remains elusive.
View Article and Find Full Text PDFObjectives: HIV viral load set points may vary between virus subtypes and host characteristics. The HIV epidemic in French Guiana entails a mix of viruses and populations of cosmopolitan origins. In this epidemiological context, we aimed to determine whether, at the scale of our territory, we could identify differences in HIV-1 viral load setpoints in our hospital cohort.
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- Researchers identified bi-allelic disruptive variants as the cause of autosomal recessive intellectual developmental disorder type 65, while dominant variants are harder to link to specific traits due to their presence in unaffected individuals.
- The study involved a retrospective analysis of 21 individuals with likely pathogenic variants, focusing on clinical information and molecular data from their families.
- Key findings revealed that those with dominant disruptive variants exhibited more developmental and behavioral problems, while individuals with dominant missense variants had a higher occurrence of renal and skin anomalies, enhancing the understanding of the related neurodevelopmental disorder.
Article Synopsis
- The CUPISCO trial is studying whether a new treatment approach called molecularly guided therapy (MGT) can help patients with a type of cancer called cancer of unknown primary (CUP) do better than the standard chemotherapy.
- This trial involved 1,505 patients from 34 countries and focused on those who showed improvement after initial chemotherapy.
- The goal is to see if using genomic profiling in deciding treatments can lead to better results in fighting cancer compared to the usual treatment options.