Gold nanoparticles as innovative therapeutics for oral mucositis: A review of current evidence.

Oral mucositis (OM) remains a debilitating side effect in patients undergoing cancer therapy. DNA damage and oxidative stress generated by radiation and/or chemotherapy activate key inflammatory pathways, ultimately resulting in the destruction of the epithelial barrier, leading to microbial colonization, and ulceration. These ulcerative lesions are often extremely painful, compromising nutrition and oral hygiene, requiring intravenous nutritional support, resulting in longer periods of hospitalization and increased cost.

AgNP/Alginate Nanocomposite hydrogel for antimicrobial and antibiofilm applications.

The synthesis and specific surface functionalization of antimicrobial silver nanoparticles (AgNPs) and their incorporation into an alginate hydrogel is described. Divalent cation-mediated ionic crosslinking was used to disperse the AgNPs throughout the gel, made possible by -COO cross-linking sites provided by the surface-enhanced nanoparticles, inspired by the classic egg-box model crosslinking of calcium alginate. An AgNP concentration, 10-20 μg g increased hygrogel elasticity, viscosity, and shear resistance by 45, 30, and 31% respectively.

Anti-biofilm activity of silver nanoparticle-containing glass ionomer cements.

Objective: To develop a silver nanoparticle (AgNP) formulation for incorporation into glass ionomer cements (GICs) which minimises biofilm growth on restoration surfaces.

Methods: GICs, Fuji IX, Ketac Molar, and Riva Selfcure were modified with 6, 10 and 24 μg per GIC capsule of α-lipoic acid-capped AgNPs. Monoculture biofilms of Streptococcus mutans were cultured (72 h) on GIC specimens (n = 3) and biofilm accumulation was quantified using a viability stain with confocal laser scanning microscopy.

Towards Dual-Functionality Spin-Crossover Complexes.

The multistep synthesis of a versatile new 4-substituted 3,5-bis(2-pyridyl)-1,2,4-triazole (Rdpt) ligand, 4-[4-(2-aminomethyl)phenyl]-3,5-bis(2-pyridyl)-4 H-1,2,4-triazole (apdpt), is reported, which features a reactive aminomethyl para-substituent on the phenyl group that points "out of the back" of the triazole. This enables further functionalisation under mild conditions by using a range of esters to form an amide link. Specifically, this proof of principle study demonstrates the synthesis of apdpt successfully appended with gold-binding thioctic acid (tpdpt), graphene-binding/emissive pyrene/propylpyrene (prdpt/pbdpt), and a Langmuir-Blodgett film-forming polyethylene glycol (PEG) tail (pgdpt).

Antimicrobial Activity of a Colloidal AgNP Suspension Demonstrated In Vitro against Monoculture Biofilms: Toward a Novel Tooth Disinfectant for Treating Dental Caries.

A novel silver nanoparticle (AgNP) formulation was developed as a targeted application for the disinfection of carious dentine. Silver nitrate (AgNO) was chemically reduced using sodium borohydrate (NaBH) in the presence of sodium dodecyl sulfate (SDS) to form micelle aggregate structures containing monodisperse 6.7- to 9.