Publications by authors named "C J Mache"
Conventional thin section electron microscopy of viral pathogens, such as the pandemic SARS-CoV-2, can provide structural information on the virus particle phenotype and its evolution. We recorded about 900 transmission electron microscopy images of different SARS-CoV-2 variants, including Alpha (B.1.
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- H9N2 influenza A viruses have become common in poultry in the Middle East and Asia, leading to an increase in human infections.
- A novel strain of H9N2 was found in Egyptian fruit bats, which shares genetic traits with current avian strains, indicating possible recent genetic mixing.
- Research shows that bat H9N2 can replicate and spread in ferrets, infect human lung tissue, and evade certain antiviral defenses, highlighting its potential risk as a pre-pandemic virus.
Article Synopsis
- Respiratory viral infections can vary significantly in severity, from symptomless cases to fatal outcomes; the mechanisms behind this variability are not fully understood.
- In a case study, a patient aged 5-15 with hemolytic uremic syndrome died from hemorrhagic pneumonia linked to a high presence of A(H1N1)pdm09 viruses with specific genetic mutations impacting their replication speed.
- Research showed that these genetic variations helped the virus thrive in the lungs, leading to significant cellular damage and a rapid progression of severe respiratory illness.
Neonatal sclerosing cholangitis (NSC) is associated with progressing biliary fibrosis that often requires liver transplantation in childhood. Several recent studies have identified variants in DCDC2, encoding doublecortin domain-containing protein 2 (DCDC2), expressed in primary cilia, that accompany syndromic disease and NSC. We report four patients with hepatobiliary disease associated with two novel homozygous or compound heterozygous variants in DCDC2.
View Article and Find Full Text PDFThis article has been withdrawn due to a publisher error that caused it to be duplicated. The definitive version of this article is published under https://doi.org/10.
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