Accelerating genomic workflows using NVIDIA Parabricks.

Background: As genome sequencing becomes better integrated into scientific research, government policy, and personalized medicine, the primary challenge for researchers is shifting from generating raw data to analyzing these vast datasets. Although much work has been done to reduce compute times using various configurations of traditional CPU computing infrastructures, Graphics Processing Units (GPUs) offer opportunities to accelerate genomic workflows by orders of magnitude. Here we benchmark one GPU-accelerated software suite called NVIDIA Parabricks on Amazon Web Services (AWS), Google Cloud Platform (GCP), and an NVIDIA DGX cluster.

Sleep-Related Breathing Problem Trajectories Across Early Childhood and Academic Achievement-Related Performance at Age Eight.

Childhood sleep disordered breathing (SDB) has been linked to poorer academic performance; however, research has not investigated the extent improvement in SDB may alter outcomes across key academic skills. This study aimed to investigate if children's early SDB status could predict later academic outcomes, and if an improvement in SDB status across the early childhood years would coincide with better, later performance in key academic skills related to reading, numeracy, and listening comprehension. Eighty five case children with an SDB symptom score >25 (maximum 77) were matched to 85 control children (score <12) at recruitment (age 3).

The proliferation and clonal migration of B cells in the systemic and mucosal tissues of channel catfish suggests there is an interconnected mucosal immune system.

IgM transcripts from different mucosal and systemic tissues from a single adult channel catfish have been evaluated. Arrayed heavy chain cDNA libraries from each of these different mucosal and systemic tissues were separately constructed, hybridized with VH family specific probes and a variety of approaches were used to define their structural relationships. Baseline hybridization studies indicated that the tissue libraries had different VH expression patterns, and sequencing studies indicated this was not simply due to varying proportions of the same B cell population.

Gender differences in sleep hygiene practices and sleep quality in New Zealand adolescents aged 15 to 17 years.

Aim: To examine, in a nationwide sample of New Zealand adolescents, self-reported sleep hygiene, and specifically evening technology and caffeine use, and body mass index, in relation to sleep quality.

Design: Cross-sectional survey.

Participants: A total of 692 adolescents (59% girls), predominantly European (78%), with an average age of 16 years 9 months were recruited through schools, community advertising, and social media.

Contact resistance and phase slips in mesoscopic superfluid atom transport.

We have experimentally measured transport of superfluid, bosonic atoms in a mesoscopic system: a small channel connecting two large reservoirs. Starting far from equilibrium (superfluid in a single reservoir), we observe first resistive flow transitioning at a critical current into superflow, characterized by oscillations. We reproduce this full evolution with a simple electronic circuit model.