Publications by authors named "C J Langford"
Background: Traditional medical research infrastructures relying on the Centers of Excellence (CoE) model (an infrastructure or shared facility providing high standards of research excellence and resources to advance scientific knowledge) are often limited by geographic reach regarding patient accessibility, presenting challenges for study recruitment and accrual. Thus, the development of novel, patient-centered (PC) strategies (e.g.
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- - This study aimed to find plasma protein patterns that can differentiate between active and inactive giant cell arteritis (GCA) patients and healthy controls by analyzing their plasma samples.
- - Researchers collected samples from 30 GCA patients and 30 matched controls, using a high-tech proteomics assay that evaluated over 7000 proteins, identifying significant differences in protein levels related to disease activity.
- - The results revealed specific proteins linked to GCA and showed strong potential for using machine learning models to identify different disease states, although distinguishing between active and inactive states in the same patient was challenging.
General internal medicine (GIM) has predominantly been perceived as a joint specialty to be completed alongside specialty training in the United Kingdom. The Internal Medicine (IMT) Stage 2 curriculum was released in August 2022; in October 2022 the Round 2 Specialty Training recruitment included applications for the pilot GIM training programme, and in February 2023 NHS England commenced the 3-year programme. The GIM programme aims to provide run-through training for GIM to Certificate of Completion of Training (CTT).
View Article and Find Full Text PDFObjective: Signal regulatory protein α (SIRPα) is found primarily on myeloid cells, including macrophages and neutrophils; binds to CD47; and regulates phagocytosis, antigen presentation, cellular fusion, cell proliferation, and migration. Therefore, SIRPα may be involved in the pathogenesis of autoimmune diseases, including systemic vasculitis. This study aimed to assess SIRPα expression in tissue samples from patients with vasculitis.
View Article and Find Full Text PDFObjectives: To evaluate damage and clinical characteristics associated with damage in Takayasu's arteritis (TAK).
Methods: Patients with TAK enrolled in a multicentre, prospective, observational study underwent standardized damage assessment every 6 months using the Vasculitis Damage Index (VDI) and the Large-Vessel Vasculitis Index of Damage (LVVID).
Results: The study included 236 patients with TAK: 92% female, 81% Caucasian; median (25th, 75th percentile) disease duration = 2.