Publications by authors named "C J L M Meijer"
Background And Aims: Refractory celiac disease type II (RCDII) is characterized by a clonally expanded aberrant cell population in the small intestine. The role of other tissue-resident immune subsets in RCDII is unknown. Here, we characterized CD8 and CD4 T cells in RCDII duodenum at the single-cell level and .
View Article and Find Full Text PDFColposcopy referrals and CIN3 detection after triage by host cell DNA methylation and/or HPV genotyping in HPV positive women with low-grade cytology from a population-based Dutch primary HPV screening trial.
Int J Cancer
March 2025
High-risk HPV (hrHPV)-based screening has led to many unnecessary colposcopy referrals, mainly because of direct referral after low-grade cytology (ASC-US/LSIL). DNA methylation and genotyping tests on ASC-US/LSIL samples have the potential to significantly improve the efficiency of screening. In this study, 12 triage strategies were constructed from FAM19A4/miR124-2 or ASCL1/LHX8 methylation, HPV16/18 or HPV16/18/31/33/45 genotyping and 1-year repeat cytology.
View Article and Find Full Text PDFBackground Climate change, driven primarily by human-induced greenhouse gas (GHG) emissions, poses major risks to human health. Health care contributes 8.5% of GHG emissions in the United States.
View Article and Find Full Text PDFObjectives: To describe incidence, clinical course, diagnostic and therapeutic management and long-term follow-up of paediatric intestinal pseudo-obstruction (PIPO) in the Netherlands between 2000 and 2020.
Methods: Multicenter, national, retrospective, observational study including patients aged <18 years diagnosed with PIPO and treated between 2000 and 2020 in Dutch academic medical centres. Outcomes included demographics, incidence, symptoms, diagnostic- and treatment methods used during follow-up, number of hospital admissions and mortality.
Article Synopsis
- A study in Germany assessed the prevalence of human papillomavirus (HPV) infections among unvaccinated women aged 30 and older, revealing a 10.6% overall HPV infection rate in a population of 2,520 screened women.
- High-risk HPV (HR-HPV) accounted for 6.5% of infections, with significant findings that over half of the HR-HPV types identified were not covered by existing vaccines, highlighting a gap in vaccination efficacy.
- The study found the highest prevalence of HR-HPV in women aged 30-34 and noted that factors such as being single and smoking were associated with increased risk for HR-HPV infection.