Rnf40 Exacerbates Hypertension-Induced Cerebrovascular Endothelial Barrier Dysfunction by Ubiquitination and Degradation of Parkin.

Aims: We aimed to investigate the role of Rnf40 in hypertension-induced cerebrovascular endothelial barrier dysfunction and cognitive impairment.

Methods: We employed microarray data analysis and integrated bioinformatics databases to identify a novel E3 ligase, Rnf40, that targets Parkin. To understand the role of RNF40 in hypertension-induced cerebrovascular endothelial cell damage, we used pAAV-hFLT1-MCS-EGFP-3×Flag-mir30shRnf40 to establish an Rnf40-deficient model in spontaneously hypertensive rats (SHRs).

Prenatal diagnosis of midgut volvulus by fetal MRI: a retrospective study.

Background: Fetal midgut volvulus is a rare disease, with a high risk of potentially life-threatening fetal complications.

Purpose: The aim of this study was to retrospectively analyze the imaging findings of fetal midgut volvulus diagnosed by magnetic resonance imaging (MRI) and explore its value in non-invasive prenatal diagnosis.

Methods: A retrospective collection of data from 156 fetuses suspected of intestinal obstruction by ultrasound examination in our hospital was conducted.

Clinical Insights into Neurosyphilis Patients with Leptomeningeal Enhancement of Spinal Cord.

Background And Objectives: This study aims to report the clinical, biological, and imaging features of cross-sectional study of neurosyphilis patients with leptomeningeal enhancement of spinal cord. Here, 51 neurosyphilis patients with leptomeningeal enhancement of spinal cord positivity are described, offering a promise in terms of early diagnosis, thereby enabling timely detection and treatment.

Methods: We retrospectively included all neurosyphilis patients enrolled in this study from December 2019 to January 2024.

The association between the recurrence of atrial fibrillation and the shape of left atrial lateral ridge.

To investigate the role of the geometry of the left atrial lateral ridge (LLR) in the atrial fibrillation (AF) recurrence after radiofrequency ablation (RFA). A total of 225 patients with AF who underwent RFA for the first time were retrospectively enrolled and divided into the recurrence (n = 53) and non-recurrence (n = 172) groups. The clinical data and the volume of left atrium (LAV) and the LLR geometry were analyzed.