Publications by authors named "C J Holt"
Introduction: Triage tools are used within trauma networks to identify which injured patients should be bypassed and pre-alerted to major trauma centres. Despite the importance of treating the 'right patient in the right place at the right time', there has been no consensus on triage tool structure or content. This study aimed to identify, collate, review, summarise and recognise patterns across established major trauma triage tools.
View Article and Find Full Text PDFTools to calculate human movement patterns can benefit musculoskeletal clinicians and researchers for rehabilitation assessments. The research objective of this study was to compare two human pose estimation models (HRNet, MediaPipe) against the laboratory marker-based reference standard for joint angles and range of motion (ROM) for several movement parameters. Twenty-two healthy volunteers (Female n = 16, Male n = 6), participated to compare outputs for knee and elbow kinematics.
View Article and Find Full Text PDFShrimp allergy, the most common food allergy in the United States, affects up to 2% of the population. Its etiology is multi-factorial with the combination of genetic predisposition and environmental exposures. This review summarizes the latest diagnosis and management strategies for shrimp allergy.
View Article and Find Full Text PDFArticle Synopsis
- The TMEM16A chloride channel is being studied as a potential treatment for cystic fibrosis by improving airway hydration and reducing symptoms.
- Research using Xenopus tadpole skin revealed that TMEM16A is present in cells similar to mammalian goblet cells and functions as a calcium-activated chloride channel.
- Deleting TMEM16A led to abnormal mucin maturation and disrupted mucus quality, indicating its critical role in maintaining a healthy mucus barrier.
Article Synopsis
- - The research focuses on developing pan-coronavirus interventions by identifying 50 antibodies from human B cells, particularly highlighting the antibody 54043-5, which binds to a common part of spike proteins in various coronaviruses.
- - A structural analysis revealed that 54043-5 recognizes a specific, highly conserved region of the S2 subunit in SARS-CoV-2, which is critical for understanding how this antibody can potentially provide protection.
- - Although 54043-5 does not neutralize the virus directly, it activates immune responses that help combat infections, and certain modifications to this antibody showed protective effects in mouse models of SARS-CoV-2 disease.