Publications by authors named "C J Hannan"
The variability in vestibular schwannoma growth rates greatly complicates clinical treatment. Management options are limited to radiological observation, surgery, radiotherapy and, in specific cases, bevacizumab therapy. As such, there is a pressing requirement for growth restricting drugs for vestibular schwannoma.
View Article and Find Full Text PDFAromatase inhibitors are increasingly being used as adjuvant therapy for hormone-responsive cancers. These drugs may reduce the endogenous estrogen production in the cerebellum. Prolonged use has been associated with symptoms such as ataxia, poorer balance performance and diminished verbal memory, suggesting impaired cerebellar function.
View Article and Find Full Text PDFBackground And Objectives: Intraoperative MRI (iMRI) has been demonstrated to improve the extent of resection of pituitary neuroendocrine tumors resected using endoscopic endonasal approaches. We sought to establish if preoperative clinicoradiological parameters could be used to predict which patients are most likely to benefit from iMRI and thus allow more efficient use of this technology.
Methods: A prospectively maintained surgical database of all endoscopic pituitary tumor resections with iMRI guidance performed between May 2017 and September 2023 was accessed.
Aims: WHO Grade 3 (G3) meningiomas are rare tumours with limited data to guide management. This retrospective study documents UK management approaches across 14 centres over 11 years.
Materials And Methods: Patients with WHO G3 meningioma between 01/01/2008 and 31/12/2018 were identified.
Article Synopsis
- The study investigates the potential long-term effects of radiation treatment, particularly focusing on the rare occurrence of radiation-induced vestibular schwannomas (VSs) among patients who received radiation that covered the posterior fossa.* -
- A review of eight cases revealed that patients had a median age of 15 years at the time of radiation and were diagnosed with VS a median of 51 years later, with some tumor characteristics noted, such as adherence to the facial nerve.* -
- The findings suggest that while the occurrence of radiation-induced VS is rare, more research is needed to understand its causative relationship with radiation exposure and to improve management strategies for affected patients.*