Publications by authors named "C J Hamilton"
Background: Myocarditis is an inflammation of the heart muscle most often caused by viral infections. Sex differences in the immune response during myocarditis have been well described but upstream mechanisms in the heart that might influence sex differences in disease are not completely understood.
Methods: Male and female BALB/c wild type mice received an intraperitoneal injection of heart-passaged coxsackievirus B3 (CVB3) or vehicle control.
Article Synopsis
- The study aimed to assess changes in cardiac [123I]-metaiodobenzylguanidine uptake in individuals with mild cognitive impairment with Lewy bodies (MCI-LB) who initially had normal scans.
- Eight participants underwent follow-up scans 2 to 4 years after their baseline assessments, with all repeat scans also returning normal results.
- Despite normal scans, three participants showed a significant decrease in uptake (over 10%) and the overall mean change in uptake was a decline of 5.2%.
Background: Autistic people without intellectual disabilities have increased perceptual capacity: they can process more information at any given time compared to non-autistic people. We examined whether increased perceptual capacity is evident across the autistic spectrum (i.e.
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- Prospective memory (PM) impairment is a frequent issue following moderate to severe traumatic brain injury (TBI), often treated with compensatory strategy training (COMP) and rehabilitation.
- This study investigates how COMP affects white matter integrity in TBI patients, using advanced diffusion MRI techniques to assess brain changes.
- Results show that the COMP group experienced less neural degeneration compared to those receiving routine care, suggesting that the intervention may help preserve brain function post-injury.
Characterization of a novel ovine model of hypertensive heart failure with preserved ejection fraction.
Am J Physiol Heart Circ Physiol
December 2024
Article Synopsis
- There is a significant need for better animal models to study heart failure with preserved ejection fraction (HFpEF), as current models do not adequately represent the condition and hinder research on treatments.
- A new model using older female sheep with chronic hypertension was developed, showing key characteristics of HFpEF, such as higher blood pressure and signs of heart dysfunction without obvious systolic impairment.
- This sheep model also exhibited decreased exercise capacity, making it a promising tool for further research to understand HFpEF and potentially improve therapy options.