Publications by authors named "C J H van de Velde"
Article Synopsis
- In early-stage breast cancer (EBC) patients, there is a need for biomarkers to predict the risk of late recurrence and the benefit from extended endocrine therapy (EET), specifically using the MammaPrint 70-gene assay to identify low-risk tumors.
- The study analyzed postmenopausal women with hormone receptor-positive EBC from the IDEAL trial to see if the MammaPrint assay could help decide between 2.5 years and 5 years of treatment with letrozole.
- Results showed that patients with low-risk tumors had a significant benefit of 10.1% for distant recurrence with longer treatment, while no significant benefits were found for high-risk or ultralow risk patients regarding treatment duration
Article Synopsis
- This study explores the significance of tumor budding (TB) in colorectal cancer, particularly focusing on intratumoral budding (ITB) in resection specimens and its feasibility in biopsy samples.* -
- The research found that high-grade TB, whether intratumoral or peritumoral, is linked with worse outcomes such as advanced cancer stages and lower overall survival rates.* -
- Results indicated that ITB is a strong predictor of overall survival and can help in improving risk assessment and predicting responses to neoadjuvant therapy in cancer patients, highlighting the need for TB evaluation in biopsies.*
Background: The Cancer Genome Atlas (TCGA) recognizes four molecular subgroups of gastric cancer: Epstein-Barr virus (EBV) positive, microsatellite instable (MSI), genomically stable (GS), and chromosomal instable (CIN). Since a GS/CIN classifier is lacking, alternative markers such as Lauren's histopathology or CDH1/p53 immunohistochemistry are commonly applied. Here we compared survival of gastric cancer subgroups determined by four methods.
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- Organ preservation through the Watch and Wait (WW) approach in rectal cancer patients shows promise but poses a risk of local regrowth (LR), leading to higher rates of distant metastases (DM) compared to traditional surgery (TME).
- A study comparing 508 LR patients managed by WW and 893 near-complete pathologic response (nPCR) patients after TME found a significantly higher DM rate in the LR group (22.8% vs. 10.2%).
- The research concluded that patients with LR have poorer 3-year DM-free survival (75% vs. 87%) and highlight that leaving a primary undetectable tumor can result in worse overall outcomes.
Background: The prognostic significance of T-cell densities in gastric cancer (GC) was previously demonstrated in surgical resection specimens. For prognosis or response prediction, it is preferable to identify biomarkers in pre-treatment biopsies; yet, its representativeness of the tumor immune microenvironment is unclear.
Objectives: This study aimed to evaluate the concordance and prognostic value of T-cell densities in paired biopsies and resections.