The clinical utility of routine postoperative hemoglobin and creatinine after reconstructive surgery for apical pelvic organ prolapse.

Introduction And Hypothesis: Postoperative laboratory tests are routinely ordered after apical prolapse repair on asymptomatic patients. We hypothesize that routine serum hemoglobin (Hb) and creatinine (Cr) have limited clinical utility in the postoperative period in asymptomatic patients.

Methods: This is a retrospective cohort study of patients who underwent surgical repair of apical prolapse between 2017 and 2019 at our institution.

A protein interaction map of the mitotic spindle.

The mitotic spindle consists of a complex network of proteins that segregates chromosomes in eukaryotes. To strengthen our understanding of the molecular composition, organization, and regulation of the mitotic spindle, we performed a system-wide two-hybrid screen on 94 proteins implicated in spindle function in Saccharomyces cerevisiae. We report 604 predominantly novel interactions that were detected in multiple screens, involving 303 distinct prey proteins.

Demonstration that acid-ethanol extracts of rat adipose tissue contain an inhibitor of food intake in the mouse.

The recent identification of the mouse obese (ob) gene, whose product is a approximately 16 kd protein secreted from adipose tissue, and the demonstration that the administration of recombinant OB protein inhibits food intake have led us to report a 1979 pilot study demonstrating an extractable activity from rat adipose tissue that inhibited food intake in the normal mouse. Two hundred grams of rat adipose tissue and 40 gm of rat muscle were extracted with acid-ethanol. The aqueous phase was lyophilized, and a filtered solution of the crude powder was injected subcutaneously daily into normal male mice.

Effect of glucose on uptake of radiolabeled glucose, 2-DG, and 3-O-MG by the perfused rat liver.

In the transition from the fasting to the fed state, plasma glucose levels rise, and the liver converts from an organ producing glucose to one of storage. To determine the effect of glucose on hepatic glucose uptake, radiolabeled glucose, 2-deoxyglucose, and 3-O-methylglucose were injected into perfused rat livers during different nontracer glucose levels, and the concentrations in the outflow were measured. A mathematical model was developed that described the behavior of the injected compounds as they traveled through the liver and was used to simulate and fit the experimental results.

Accelerated cholesteryl ester transfer in baboons with insulin-requiring diabetes mellitus.

Cholesteryl ester transfer (CET), plasma, lipoprotein lipid and phospholipid composition were studied in insulin-treated baboons with chronic streptozotocin-induced diabetes. In these diabetic animals, CET measured both as the mass (p < 0.001) and isotopic transfer (p < 0.