Publications by authors named "C J Giroud"
The S100 protein family functions as protein-protein interaction adaptors regulated by Ca binding. Formation of various S100 complexes plays a central role in cell functions, from calcium homeostasis to cell signaling, and is implicated in cell growth, migration, and tumorigenesis. We established a suite of biochemical and cellular assays for small molecule screening based on known S100 protein-protein interactions.
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- Root exudates play a crucial role in influencing the plant's root microbiome through specialized metabolites, particularly benzoxazinoids in maize.
- Researchers discovered that certain bacteria in the maize rhizosphere can metabolize these compounds, specifically MBOA (6-methoxybenzoxazolin-2(3H)-one), into AMPO (2-amino-7-methoxy-phenoxazin-3-one).
- A gene cluster containing bxdA, which encodes a key enzyme for this conversion, was identified, highlighting how specific bacteria able to metabolize benzoxazinoids can thrive and influence the soil environment around maize roots.
Article Synopsis
- - The 2A protease of enterovirus species, responsible for critical steps in viral replication, is a key target for combating pediatric hand-foot-and-mouth disease and preparing for potential outbreaks.
- - Inhibiting the 2A protease can disrupt the folding and assembly of viral capsid proteins, preventing the production of mature viral particles and presenting a strategy for antiviral treatment.
- - A crystallographic fragment screening campaign successfully identified 75 compounds that bind to the 2A protease, with 38 unique ones targeting the active site, paving the way for the creation of broad-spectrum anti-enteroviral drugs.
Article Synopsis
- - Zika virus (ZIKV) infections are linked to serious health issues like microcephaly in newborns and Guillain-Barre syndrome in adults, with no current vaccines or antiviral treatments available.
- - The NS3 protease and its co-factor NS2B play a crucial role in processing viral proteins, making them a key target for drug development.
- - A successful crystallographic study identified 48 compounds that bind to the NS2B-NS3 protease, along with 6 additional fragments targeting a possible allosteric site, paving the way for new inhibitors to be developed.
JET's frequency-modulated continuous wave (FMCW) reflectometers have been operating well with the current design since 2005, and density profiles have been automatically calculated intershot since then. However, the calculated profiles had long suffered from several shortcomings: poor agreement with other diagnostics, sometimes inappropriately moving radially by several centimeters, elevated levels of radial jitter, and persistent wriggles (strong unphysical oscillations). In this research, several techniques are applied to the reflectometry data analysis, and the shortcomings are significantly improved.
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