Publications by authors named "C J Germain"
France has been engaged in a legal and organisational transition for many years. It has had to adapt its national framework to the legal requirements of personal data protection, European ambitions and international competition. From the Data Protection Act of 1978 to the Healthcare System Transformation Act of 2019, reforms have strengthened requirements in terms of personal data protection, while opening the way to innovative uses.
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- - The study explores how Lassa fever develops and the factors that determine whether it results in a mild or severe illness, using a monkey model to replicate different disease outcomes.
- - It finds that lymphoid organs are key early sites for the replication of the Lassa virus, which can enter through lymph node structures regardless of whether the infection is fatal or not.
- - The severity of the disease correlates with how the virus spreads; in nonfatal cases, it largely stays within lymphoid tissues, while fatal outcomes see the virus invade multiple organs, triggering a strong immune inflammatory response.
Tertiary Lymphoid Structures (TLS) are considered as genuine markers of inflammation. Their presence within inflamed tissues or the tumor microenvironment has been associated with the local development of an active immune response. While high densities of TLS are correlated with disease severity in autoimmune diseases or during graft rejection, it has been associated with longer patient survival in many cancer types and more recently with positive responses to anti-PD-1 immunotherapy.
View Article and Find Full Text PDFIntroduction: Despite technological advances, the use of homologous blood to prime the cardiopulmonary bypass (CPB) circuits of infants under 10 kg remains common. However, such rapid massive transfusion may increase post-CPB morbidity.
Method: We retrospectively included consecutive patients weighing 2.