Publications by authors named "C J Gaskell"
Background: Myelofibrosis (MF) is a clonal haematopoietic disease, with median overall survival for patients with primary MF only 6.5 years. The most frequent gene mutation found in patients is JAK2, causing constitutive activation of the kinase and activation of downstream signalling.
View Article and Find Full Text PDFBackground: The relationship between obesity, physical activity, and cancer has not been well studied across different countries. The age-standardized rate of cancer in the UK is double-triple that in the Gulf Cooperation Council Countries (GCCCs). Here, we study the association between obesity, physical activity, and cancer incidence with the aim to elucidate cancer epidemiology and risk factors in two geographically, ethnically, and climatically different parts of the world.
View Article and Find Full Text PDFArticle Synopsis
- This study reviews the effectiveness of psychological interventions for functional/dissociative seizures (FDS) through a systematic analysis of data from 44 studies involving 1,300 patients.
- The meta-analysis found a 40% seizure freedom rate at treatment's end and a 66% rate of ≥50% improvement in seizure frequency during treatment, indicating moderate positive effects from psychological therapies.
- Despite improvements in seizure-related outcomes, none of the explored factors significantly affected seizure freedom, highlighting the need for more research on optimal measures to evaluate FDS severity.
The emPHasis-10 is a health-related quality of life (HRQoL) unidimensional measure developed specifically for adults with pulmonary hypertension. The tool has excellent psychometric properties and is well used in research and clinical settings. Its factor structure has not been examined, which may help to identity a complimentary approach to using the measure to examine patient functioning.
View Article and Find Full Text PDFBackground: Well-designed evaluations of psychological interventions on psychiatric intensive care units (PICUs) are a rarity.
Aims: To evaluate the effectiveness of cognitive behaviour therapy for intrusive taboo thoughts with a patient diagnosed with bipolar affective disorder admitted to a PICU due to significant ongoing risk of harm to self.
Method: This was a four-phase ABC plus community follow-up (D) mixed methods =1 single case experimental design.