Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr-/-.Leiden mice.

Fibroblast growth factor 21 (FGF21) is a promising target for treatment of obesity-associated diseases including metabolic dysfunction-associated steatohepatitis (MASH) and atherosclerosis. We evaluated the effects of the bispecific anti-FGF21-β klotho (KLB) agonist antibody bFKB1 in a preclinical model of MASH and atherosclerosis. Low-density lipoprotein receptor knockout (Ldlr-/-).

On-field concurrent validity of flight time-based countermovement jump height during fatigue: A comparison between inertial measurement units worn at different locations on the body.

We explored the feasibility of utilizing immediate changes in flight time-based vertical countermovement jump height as an on-field measure for fatigue-induced decrements in performance. Comparing Inertial Measurement Units (IMUs) worn at five body locations (feet, shorts for thighs and pelvis, waist strap, and thorax in a standard GPS vest) with a force plate as a reference, we enlisted 19 amateur football players who performed a series of 10 maximal 30 m sprints (initiated every minute). Maximal jumps were executed immediately before and after each sprint, with the latter jumps recorded on a force plate integrated into the field.

Different Aspects of Physical Load in Small-Sided Field Hockey Games.

Wilmes, E, de Ruiter, CJ, van Leeuwen, RR, Banning, LF, van der Laan, D, and Savelsbergh, GJP. Different aspects of physical load in small-sided field hockey games. J Strength Cond Res 38(2): e56-e61, 2024-Running volumes and acceleration/deceleration load are known to vary with different formats of small-sided games (SSGs) in field hockey.

Self-perceived views on offender rehabilitation in detained adolescent boys: a qualitative analysis in the context of the good lives model.

Introduction: An upcoming offender rehabilitation model, the Good Lives Model (GLM), proposes that effective offender rehabilitation should adopt a focus: reducing recidivism risk enhancing the offender's well-being. To achieve this, the GLM suggests rehabilitation should include the prosocial fulfilment of a universal set of human needs termed "primary goods." A focus on primary goods attainment and well-being is hypothesized to improve treatment motivation and achieve more sustainable desistance from future offending.