Identification of novel candidate genes for Ascochyta blight resistance in chickpea.

Ascochyta blight, caused by the necrotrophic fungus Ascochyta rabiei, is a major threat to chickpea production worldwide. Resistance genes with broad-spectrum protection against virulent A. rabiei strains are required to secure chickpea yield in the US Northern Great Plains.

Implicit bias in the patient descriptor "homeless" and its association with emergency department opioid administration and disposition.

Background: Biased language in provider documentation of marginalized patient populations has been shown to negatively influence patient management. There has been debate over the use of "homeless" as a descriptor of people experiencing homelessness (PEH), as it is a potentially biased term with negative connotations. This study explores the relationship between the use of the word "homeless" in Emergency Department (ED) provider documentation and admission rates, as well as intravenous (IV) vs.

Acupuncture in the emergency department (ACUITY): Results from a BraveNet multi-center feasibility randomized controlled trial.

Background: Pain plays a significant role in emergency department (ED) visits, however safe and effective nonpharmacologic options are needed. Prior studies of acupuncture in the ED reported pain reduction with minimal side effects, but most were small and single site.

Methods: We conducted ACUITY, a prospectively designed multi-center feasibility RCT.

Spontaneous Tumor Lysis Syndrome in the Setting of Pancreatic Adenocarcinoma.

Tumor lysis syndrome (TLS) is the destruction of tumor cells, causing the release of intracellular contents, including but not limited to uric acid, phosphate, and potassium. This can manifest with significant physiologic abnormalities, such as life-threatening acute kidney injury. Although TLS is usually caused by the initiation of cytotoxic chemotherapy, it may also occur spontaneously, particularly in high-grade malignancies with high tumor burden and/or rapid cell turnover.

In utero human cytomegalovirus infection expands NK-like FcγRIII+CD8+ T cells that mediate Fc antibody functions.

Human cytomegalovirus (HCMV) profoundly impacts host T and NK cells across the lifespan, yet how this common congenital infection modulates developing fetal immune cell compartments remains underexplored. Using cord blood from neonates with and without congenital HCMV (cCMV) infection, we identify an expansion of Fcγ receptor III-expressing (FcγRIII-expressing) CD8+ T cells following HCMV exposure in utero. Most FcγRIII+CD8+ T cells express the canonical αβ T cell receptor (TCR), but a proportion express noncanonical γδ TCR.