Publications by authors named "C J Clancy"
Introduction: To investigate the current evidence regarding long-term outcomes using laparoscopic peritoneal lavage (LPL) versus primary bowel resection (PR) in Hinchey III diverticulitis.
Methods: A systematic review was undertaken based upon articles published between 1st January 2000 and 1st March 2024. Databases Pubmed, Scopus and Embase were used employing the key search terms "diverticulitis" and "peritoneal lavage".
International Development Organisations (IDOs) undertake critical work to improve the lives of people across the world, particularly in the Global South [...
View Article and Find Full Text PDFThe human voltage-gated sodium channel Na1.5 (hNa1.5/SCN5A) plays a critical role in the initiation and propagation of action potentials in cardiac myocytes, and its modulation by various drugs has significant implications for cardiac safety.
View Article and Find Full Text PDFArticle Synopsis
- - Alphaviruses pose a threat to public health, and two monoclonal antibodies (mAbs), SKT05 and SKT20, show promise in providing protection against Venezuelan equine encephalitis virus (VEEV) in mouse models.
- - SKT20's effectiveness relies on Fc effector functions to prevent death from VEEV, while SKT05 can control viral spread and replication without these functions initially, but requires them later for full efficacy.
- - The study highlights how antibody avidity (strength of binding) is crucial for mAb effectiveness and suggests that understanding Fc-dependent mechanisms can help in developing better therapeutic treatments for alphavirus infections.
Article Synopsis
- Within-patient diversity in bloodstream infections (BSIs) was investigated by sequencing strains from blood cultures of 4 patients, revealing mixed populations in 3 of them with significant genetic variations.
- One strain variant with chromosome 7 trisomy (Tri7) from patient MN showed different growth behaviors and competitiveness compared to its euploid counterpart during infections and antifungal treatments.
- The study suggests that diverse strain populations exist in BSIs, which could impact treatment outcomes and highlight the need for further research into their clinical significance and antifungal resistance.