Retroperitoneal Nodal Distribution for Metastatic Seminoma: Is Modified Template Appropriate? A Retrospective Study.

Purpose: Several phase 2 trials have investigated the efficacy of retroperitoneal lymph node dissection (RPLND) with a unilateral modified template as the first-line treatment for stage II seminoma. However, the rationale for using modified templates is extrapolated from studies of nonseminomatous germ cell tumor. In this retrospective study, we sought to compare the oncologic outcome of bilateral and unilateral templates and perform a clinical mapping study for metastatic seminoma.

Prediction Model for Brain Metastasis in Patients With Metastatic Germ-Cell Tumors.

Background: Brain metastasis (BM) is an independent adverse prognostic factor in metastatic germ cell tumors (mGCT). We aimed to establish an effective and practical BM prediction model.

Patients And Methods: Between January 1990 and September 2017, 2291 patients with mGCT who were treated at Indiana University were identified.

Changes in Reproductive Health Information-Seeking Behaviors After the Dobbs Decision: Systematic Search of the Wikimedia Database.

Background: After the US Supreme Court overturned Roe v. Wade, confusion followed regarding the legality of abortion in different states across the country. Recent studies found increased Google searches for abortion-related terms in restricted states after the Dobbsv.

Primary retroperitoneal lymph node dissection in clinical stage 2a/b non-seminomatous germ cell tumour.

Objectives: To reassess the role of primary retroperitoneal lymph node dissection (RPLND) in patients with marker-negative non-seminomatous germ cell tumour (NSGCT) clinical stage (CS) 2a, to explore results in patients with CS 2b and to evaluate surgical methods, recurrence, and adjuvant chemotherapy indications.

Materials And Methods: Data from 17 institutions were collected, comprising 305 men who underwent primary RPLND for CS 2 NSGCT. Regression analyses were conducted to predict histology in the RPLND specimen and disease-free survival (DFS).

Unexpected Delayed Incursion of Highly Pathogenic Avian Influenza H5N1 (Clade 2.3.4.4b) Into the Antarctic Region.

The current highly pathogenic avian influenza H5N1 panzootic is having substantial impacts on wild birds and marine mammals. Following major and widespread outbreaks in South America, an incursion to Antarctica occurred late in the austral summer of 2023/2024 and was confined to the region of the Antarctic Peninsula. To infer potential underlying processes, we compiled H5N1 surveillance data from Antarctica and sub-Antarctic Islands prior to the first confirmed cases.