Publications by authors named "C J Bromhead"
Article Synopsis
- E171 (titanium dioxide) is a common food additive found in various products, but its safety is debated due to lacking thorough risk assessments.
- Research indicates that titanium dioxide nanoparticles (TiO NPs) can be toxic to multiple organs, particularly the liver, causing inflammation, cell death, and other significant changes.
- This review aims to shed light on the harmful effects of orally ingested TiO NPs specifically on the liver while addressing the ongoing controversies regarding their toxicity.
Development of a non-infectious control for viral hemorrhagic fever PCR assays.
PLoS Negl Trop Dis
April 2024
Assay validation is an essential component of disease surveillance testing, but can be problematic in settings where access to positive control material is limited and a safety risk for handlers. Here we describe a single non-infectious synthetic control that can help develop and validate the PCR based detection of the viral causes of Crimean-Congo hemorrhagic fever, Ebola virus disease, Lassa fever, Marburg virus disease and Rift Valley fever. We designed non-infectious synthetic DNA oligonucleotide sequences incorporating primer binding sites suitable for five assays, and a T7 promotor site which was used to transcribe the sequence.
View Article and Find Full Text PDFCardiovascular diseases (CVDs) are the leading cause of death worldwide. Currently, cardiovascular disease risk algorithms play a role in primary prevention. However, this is complicated by a lack of powerfully predictive biomarkers that could be observed in individuals before the onset of overt symptoms.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how adding heavy metals from superphosphate fertilizers to agricultural soil affects soil bacteria's resistance to both heavy metals (HMs) and antibiotics (Ab) over a 6-week incubation period.
- - Researchers assessed this co-resistance by using plate culture tests and pollution-induced community tolerance (PICT) assays, focusing on bacterial diversity through specific DNA sequencing techniques.
- - Findings revealed that soil bacteria communities exposed to heavy metals displayed significant changes in composition compared to control groups, suggesting a link between heavy metal exposure and increased antibiotic resistance in soil bacteria.