Publications by authors named "C J Baines"

Article Synopsis
  • The mitochondrial permeability transition (MPT) pore is linked to necrotic cell death in the heart, with Cyclophilin D (CypD) identified as a key regulator of this pore.
  • Researchers discovered that Complement 1q-binding protein (C1qbp) interacts with CypD and could inhibit cell death in heart cells, leading them to hypothesize C1qbp would protect against MPT-related cell loss in live models.
  • Experiments with transgenic mice showed that while C1qbp influences mitochondrial functioning and heart remodeling post-infarction, it does not significantly alter MPT activity or overall heart morphology and function.
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The last few years have seen a surge of interest from field ecologists and evolutionary biologists to study neoplasia and cancer in wildlife. This contributes to the One Health Approach, which investigates health issues at the intersection of people, wild and domestic animals, together with their changing environments. Nonetheless, the emerging field of wildlife cancer is currently constrained by methodological limitations in detecting cancer using non-invasive sampling.

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Context-dependent dispersal allows organisms to seek and settle in habitats improving their fitness. Despite the importance of species interactions in determining fitness, a quantitative synthesis of how they affect dispersal is lacking. We present a meta-analysis asking (i) whether the interaction experienced and/or perceived by a focal species (detrimental interaction with predators, competitors, parasites or beneficial interaction with resources, hosts, mutualists) affects its dispersal; and (ii) how the species' ecological and biological background affects the direction and strength of this interaction-dependent dispersal.

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The spread of parasites and the emergence of disease are currently threatening global biodiversity and human welfare. To address this threat, we need to better understand those factors that determine parasite persistence and prevalence. It is known that dispersal is central to the spatial dynamics of host-parasite systems.

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Parasites are known to have direct effects on host dispersal ability and motivation. Yet, parasites have a variety of impacts on host populations, including shaping predation and cannibalism rates, and therefore may also have indirect effects on host dispersal; these indirect pathways have not been studied. We tested the hypothesis that parasites influence host dispersal through effects on cannibalism using backswimmers () and Hydrachnidia freshwater mites.

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