Publications by authors named "C J Asperen"

Background: Premenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at high familial risk of ovarian cancer leads to immediate menopause. Although early natural menopause is associated with increased cardiovascular disease risk, evidence on long-term cardiovascular disease risk after early surgical menopause is scarce.

Objectives: We sought to determine the long-term influence of the timing of RRSO on the development of coronary artery calcium (CAC), an established marker for cardiovascular disease risk.

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Article Synopsis
  • Risk-reducing salpingo-oophorectomy (RRSO) significantly lowers the risk of high-grade serous carcinoma (HGSC) in women carrying BRCA1/2 genetic variants, but some still develop HGSC after the procedure.
  • A study involving 2,519 women found that the 20-year cumulative incidence of HGSC was low (1.5% for BRCA1 and 0.2% for BRCA2 carriers), with particular risk factors identified, such as older age at RRSO and incomplete embedding of RRSO specimens.
  • Implementing strict guidelines for timely RRSO and ensuring complete specimen embedding could further minimize the risk of developing HGSC in these patients
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Functional analyses are the main method to classify mismatch repair (MMR) gene variants of uncertain significance (VUSs). However, the pathogenicity remains unclear for many variants because of conflicting results between clinical, molecular, and functional data. In this study, we evaluated whether whole exome sequencing (WES) could add another layer of evidence to elucidate the pathogenicity of MMR variants with conflicting interpretations.

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Article Synopsis
  • The c.1100delC genetic variant is linked to a higher risk of breast cancer in women, with research focusing on its effects within a Dutch study cohort, Hebon, which initially centered on known breast cancer-related genetic variants.
  • The study included 1,802 female participants, revealing that carriers of c.1100delC were diagnosed with breast cancer at younger ages and had specific cancer characteristics compared to non-carriers.
  • Future research aims to enhance understanding of breast cancer risk in women who test negative but are from families with c.1100delC, utilizing ongoing data from the Netherlands Cancer Registry.
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Article Synopsis
  • The study checked how well the BOADICEA model predicts breast cancer risk for people who carry certain gene changes (called pathogenic variants).
  • They looked at information from a group of over 1,600 participants and found that the model worked really well, especially when considering family history and other risk factors.
  • The results can help doctors and patients make better choices about cancer management, and the model can be accessed for free on the CanRisk website.
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