Publications by authors named "C J Alteri"
Article Synopsis
- A cluster of four patients with CRAB, who had never been treated with FDC, showed non-susceptibility to FDC due to a specific mutation in the PirA protein, which included a premature stop codon and amino acid deletion.
- Between March and July 2024, 33 CRAB cases were identified in a single hospital ward, with genetic analysis revealing that four of these cases were closely related variants showing reduced FDC susceptibility.
- The study emphasizes the need for careful testing of FDC susceptibility in patients, as the identified clones suggest possible transmission of resistant strains even in those without prior treatment.
: Carbapenem-resistant (CRE) are types of bacteria that need urgent attention globally. Active surveillance programs at hospitals are essential for the early identification of CRE carriers and the timely adoption of infection control measures. We aimed to analyze the epidemiology of CRE identified by multiplex RT-PCR in rectal swabs of patients upon admission to high-risk wards and to compare data obtained from both molecular and culture CRE screening.
View Article and Find Full Text PDFObjectives: Genomic surveillance of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) is crucial for virulence, drug-resistance monitoring, and outbreak containment.
Methods: Genomic analysis on 87 KPC-Kp strains isolated from 3 Northern Italy hospitals in 2019-2021 was performed by whole genome sequencing (WGS), to characterize resistome, virulome, and mobilome, and to assess potential associations with phenotype resistance and clinical presentation. Maximum Likelihood and Minimum Spanning Trees were used to determine strain correlations and identify potential transmission clusters.
Article Synopsis
- Surveillance of SARS-CoV-2 variants is essential for public health decisions, with a study focusing on their dynamics in Cameroon from April 2020 to August 2022.
- The research involved analyzing SARS-CoV-2 positive samples using Sanger sequencing and SNPsig® SARS-CoV-2 EscapePLEX to evaluate their effectiveness in detecting variants.
- Results showed a shift in dominant variants across different waves, with significant prevalence of the Omicron variant in the latest wave, indicating that SNPsig® is a reliable tool for variant detection, although improvements are needed for identifying Omicron sub-lineages.
The ectopic gut colonization by orally derived pathobionts has been implicated in the pathogenesis of various gastrointestinal diseases, including inflammatory bowel disease (IBD). For example, gut colonization by orally derived spp. has been linked to IBD in mice and humans.
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