Publications by authors named "C J Ade"
The contribution of deubiquitylating enzymes (DUBs) to β-Catenin stabilization in intestinal stem cells and colorectal cancer (CRC) is poorly understood. Here, and by using an unbiassed screen, we discovered that the DUB USP10 stabilizes β-Catenin specifically in APC-truncated CRC in vitro and in vivo. Mechanistic studies, including in vitro binding together with computational modelling, revealed that USP10 binding to β-Catenin is mediated via the unstructured N-terminus of USP10 and is outcompeted by intact APC, favouring β-catenin degradation.
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- The PREVENT equations were developed by the American Heart Association to improve the assessment of cardiovascular disease (CVD) risk, aiming to facilitate treatment initiation and enhance communication between patients and clinicians.* -
- The study utilized National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2010, focusing on a diverse US adult population with a 10-year follow-up to evaluate the effectiveness of these equations in predicting CVD-related mortality.* -
- Results showed that the PREVENT equations had a strong ability to predict CVD risk, with a significant association between higher risk estimates and increased mortality, achieving a high discrimination score, although exhibiting some moderate underfitting in the model.*
Long noncoding (lnc)RNAs emerge as regulators of genome stability. The nuclear-enriched abundant transcript 1 (NEAT1) is overexpressed in many tumors and is responsive to genotoxic stress. However, the mechanism that links NEAT1 to DNA damage response (DDR) is unclear.
View Article and Find Full Text PDFWe investigated second-messenger signalling components linked to the stimulation of G protein-coupled receptors (e.g. thromboxane A and bradykinin B2 receptors) on the sensory endings of thin fibre muscle afferents in the chronic mechanoreflex sensitization in rats with myocardial infarction-induced heart failure with reduced ejection fraction (HF-rEF).
View Article and Find Full Text PDFMYC family oncoproteins regulate the expression of a large number of genes and broadly stimulate elongation by RNA polymerase II (RNAPII). While the factors that control the chromatin association of MYC proteins are well understood, much less is known about how interacting proteins mediate MYC's effects on transcription. Here, we show that TFIIIC, an architectural protein complex that controls the three-dimensional chromatin organisation at its target sites, binds directly to the amino-terminal transcriptional regulatory domain of MYCN.
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