Publications by authors named "C J Ackerman"
Unlabelled: Plasma cell neoplasia has a wide presentation of disease (localised or systemic) according to the International Myeloma Working Group. Radiological imaging identifies plasmacytomas as solitary lesions or part of multiple myeloma. We present a rare case of a 21-year-old female who presented with a skull-base tumour.
View Article and Find Full Text PDFPurpose: To evaluate organ at risk (OAR) auto-segmentation in the head and neck region of computed tomography images using two different commercially available deep-learning-based auto-segmentation (DLAS) tools in a single institutional clinical applications.
Methods: Twenty-two OARs were manually contoured by clinicians according to published guidelines on planning computed tomography (pCT) images for 40 clinical head and neck cancer (HNC) cases. Automatic contours were generated for each patient using two deep-learning-based auto-segmentation models-Manteia AccuContour and MIM ProtégéAI.
Article Synopsis
- Taxane-based chemotherapy, specifically paclitaxel, is commonly used for treating platinum- and immunotherapy refractory metastatic urothelial carcinoma (mUC), but survival outcomes are generally poor and biomarkers for predicting outcomes are lacking.
- A study was conducted using whole-transcriptome profiles from patients enrolled in a trial (PLUTO) to evaluate gene signatures related to survival, focusing on factors like immuno-oncology, angiogenesis, and genome instability.
- Results indicated that patients with high expressions of genome instability and evading growth suppressors experienced significantly better progression-free survival (PFS) and overall survival (OS), while activation of angiogenesis was associated with worse outcomes across both treatment cohorts.