Publications by authors named "C Ishihara"
Article Synopsis
- Bowen's disease (BD) is a precancerous skin condition that can lead to invasive tumors, while Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer usually found in sun-exposed areas.
- A case report describes an 87-year-old Japanese male with both BD and unusual subcutaneous MCC on his hand, confirmed through biopsy and immunohistochemistry.
- The patient is currently being monitored with no recurrence after six months, highlighting the rarity of this combination and the need for thorough diagnostic evaluation of atypical skin lesions.
Objectives: Oral microbiome dysbiosis prevention is important to avoid the onset and progression of periodontal disease. Dipotassium glycyrrhizate (GK2) is a licorice root extract with anti-inflammatory effects, and its associated mechanisms have been well-reported. However, their effects on the oral microbiome have not been investigated.
View Article and Find Full Text PDFObjective: The aim of this study was to quantitatively evaluate the efficacy of a self-monitoring intervention for the management of persistent chemotherapy-induced peripheral neuropathy (CIPN).
Methods: A randomized controlled clinical trial was conducted on 65 outpatients receiving taxane or platinum-based anticancer drugs. Participants were assigned to the control group (CG; = 32) or the self-monitoring group (SMG; = 33) and followed for 6 weeks.
Purpose: Our previous clinical pilot study reported that miconazole (MCZ) prevented morbidity from surgical necrotizing enterocolitis (NEC). The present study re-investigated this effect in a long-term cohort over 20 years.
Methods: We conducted a retrospective cohort study from April 1998 to March 2020.
Objectives: Periodontal disease is triggered by oral microbiome dysbiosis. Thus, to prevent its onset, it is important to maintain relative abundance of periodontal pathogenic bacteria in the oral microbiome at a low level. While Phellodendron bark extract (PBE) and its active ingredient, berberine, exert antibacterial effects on periodontal pathogenic bacteria, such as Porphyromonas gingivalis, their effects on the oral microbiome as a whole remain unknown.
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