The concentration of serum creatine-kinase in manic attacks of primary affective psychoses.

The study aims to observe whether subjects with a primary affective disease and manic attacks show modifications of serum concentration of creatine-kinase conferring it the role of a biologic marker. Serum concentration of creatine-kinase was determined for 122 men with mono- and bipolar affective disease during the different stages as well as for schizophrenic men with different clinical forms excepting the affective form. The control group included 60 men.

Serum immunoglobulin levels in schizoaffective disorders (manic and depressive).

Immunoglobulin levels (A, G, M) were measured with Mancini's radial immunodiffusion technique (RID). IgA and IgG levels showed a statistically significant increase in schizoaffective patients compared to normals, and schizophrenics, but no modification in comparison with the affective patients. IgM also showed a statistically significant increase which may constitute a trait marker for the schizoaffective disease.

Humoral immunity in Down's syndrome.

Carried out on 57 outpatients, the study was aimed to prove the existence of a disgammaglobulinemia in Down's syndrome. The event could not be attributed to hospitalization. Data indicate increased A and G immunoglobulinemias.

The serum creatine-kinase as a biologic marker in major depression.

The paper aims at finding whether the serum creatine-kinase activity may be considered as a biological state or a trait-marker in major depression. The study performed in 76 patients (males and females) led to the conclusion that significant increases of the enzymic activity as compared with controls are present in depressive and not in euthymic patients. The same significant increase was found when comparing the depressive and euthymic patients (but not in the group of monopolar depressive females).