Intricate ribosome composition and translational reprogramming in epithelial-mesenchymal transition.

Epithelial-mesenchymal transition (EMT) involves profound changes in cell morphology, driven by transcriptional and epigenetic reprogramming. However, evidence suggests that translation and ribosome composition also play key roles in establishing pathophysiological phenotypes. Using genome-wide analyses, we reported significant rearrangement of the translational landscape and machinery during EMT.

Caregiver burden during psychiatric hospitalisation: A multi-centre, longitudinal study.

What Is Known About The Subject: Caring for a family member with a mental illness induces a burden on the caregiver, an impact on their quality of life and premature ageing of more than ten years.

What The Paper Adds To Existing Knowledge: We conducted systematised and individualised nursing interviews with family members, on the first days of a relative's hospitalisation, during hospitalisation and three months after discharge. We observed persistent depressive symptoms during and after hospitalisation.

Developing a Common Global Baseline for Nucleic Acid Synthesis Screening.

Introduction: Nucleic acid synthesis is a powerful tool that has revolutionized the life sciences. However, the misuse of synthetic nucleic acids could pose a serious threat to public health and safety. There is a need for international standards for nucleic acid synthesis screening to help prevent the misuse of this technology.

Design Insights for Industrial CO Capture, Transport, and Storage Systems.

We present methods and insights for the design of CO capture, transport, and storage systems for industrial facilities with a case study focus on Louisiana. Our analytical framework includes (1) evaluating the scale and concentration of capturable CO emissions at individual facilities for the purpose of estimating the cost of CO capture retrofits that utilize various energy supply sources to meet parasitic demands; (2) screening to identify potential CO storage sites and estimate their capacities, injectivities, and costs; and (3) designing cost-minimized trucking or pipeline infrastructure connecting CO capture plants with storage sites, considering existing land uses, demographics, and a variety of social and environmental justice factors. Estimated levelized costs of capture at Louisiana's 190 industrial facilities range from below $50/tCO to above $500/tCO, depending on facility-specific features.