Publications by authors named "C Ignacio"
Background: Identifying risk factors for HIV rebound after treatment interruption is crucial for designing effective remission strategies.
Methods: Peripheral blood mononuclear cells from participants in the Zurich HIV Primary Infection Cohort (ZPHI, N=73) and ACTG study A5345 (N=44) were analyzed before ART interruption. We measured cell-associated HIV RNA, total HIV DNA, and proviral diversity (env gene).
Background: We examined HIV prevalence and transmission dynamics among people who inject drugs in the U.S./Mexico border region during the COVID-19 pandemic.
View Article and Find Full Text PDFObjective: Identify system-level features in HIV migration within a host across body tissues. Evaluate heterogeneity in the presence and magnitude of these features across hosts.
Method: Using HIV DNA deep sequencing data generated across multiple tissues from 8 people with HIV, we represent the complex dependencies of HIV migration among tissues as a network and model these networks using the family of exponential random graph models (ERGMs).
Background: In modern times, horses are utilized not only for labour and transportation purposes but also for recreational activities such as competition and pleasure riding. In these various pursuits, the role of vision plays a crucial role. Electroretinography is the most used test to diagnose diseases of the retinal outer segment.
View Article and Find Full Text PDFArticle Synopsis
- Brain microglia (MG) may function as a reservoir for HIV, potentially causing viral rebound when antiretroviral therapy (ART) is stopped, but their ability to carry active HIV has not been established until now.
- Researchers isolated brain myeloid cells (BrMCs) from both nonhuman primates and humans with HIV undergoing ART, finding that nearly all BrMCs were identified as microglia, which contained detectable HIV or SIV DNA.
- The study revealed that MG can harbor replication-competent HIV, showing it replicates in the brain and has low genetic diversity, indicating that this virus quickly adapts and spreads within brain regions.