Publications by authors named "C Ibam"
Improved methods for malaria diagnosis are urgently needed. Here, we evaluate a novel method named rotating-crystal magneto-optical detection (RMOD) in 956 suspected malaria patients in Papua New Guinea. RMOD tests can be conducted within minutes and at low cost.
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- A study in Papua New Guinea compared two artemisinin combination therapies (artemether-lumefantrine and artemisinin-naphthoquine) on children with malaria, revealing that the artemisinin-naphthoquine treatment led to a higher initial rise in Plasmodium falciparum gametocyte density.
- The time for gametocyte density to drop to a transmission-unlikely level was longer in the artemisinin-naphthoquine group (20 days) than in the artemether-lumefantrine group (16 days).
- While both treatments cleared P. vivax gametocytes quickly, the artemether-lumefantrine group had a significantly higher percentage
Background: Gametocytes are the transmission stages of Plasmodium parasites, the causative agents of malaria. As their density in the human host is typically low, they are often undetected by conventional light microscopy. Furthermore, application of RNA-based molecular detection methods for gametocyte detection remains challenging in remote field settings.
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