Publications by authors named "C I Workman"
Article Synopsis
- Cancer treatment is shifting towards immunotherapy, with immune checkpoint inhibitors (ICIs) showing promising results in improving patient survival rates.
- The FDA has recently approved a combination therapy involving LAG3 and PD1 inhibitors for advanced melanoma patients, paving the way for further research.
- Ongoing clinical trials are exploring new LAG3-targeted treatments, including bispecific antibodies that aim to reactivate exhausted T cells in the fight against cancer.
: Understanding how dual-tasking and Parkinson's disease medication affect gait and balance regularity can provide valuable insights to patients, caregivers, and clinicians regarding frailty and fall risk. However, dual-task gait and balance studies in PD most often only employ linear measures to describe movement regularity. Some have used nonlinear techniques to analyze PD performances, but only in the on-medication state.
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- This study is a retrospective analysis comparing various metrics (mean work RVUs, operative time, and efficiency measured as wRVUs/min) for single- and multilevel cervical spine fusions conducted from 2011 to 2020.
- The researchers examined data for nearly 101,000 patients, focusing on anterior cervical discectomy and fusion (ACDF) versus posterior cervical decompression and fusion (PCDF), finding that anterior fusions were typically quicker but varied in efficiency depending on the number of fusion levels.
- Results highlighted significant differences between the surgical approaches, indicating that while anterior fusions had lower wRVUs in single and multi-level procedures, they were more efficient in the 1- and 2-level categories
Article Synopsis
- Women with substance use issues during pregnancy fear losing their children and face stigmas and barriers when seeking help, such as having to repeatedly share their experiences.
- The study assessed a service coordination program for these women and their families over four years at three different sites, focusing on stakeholder interest, feasibility, and program effectiveness.
- A total of 182 women and their families participated, receiving support from patient navigators, and the program proved to be effective and satisfactory, with participants staying for an average of 655 days.
EBV-induced gene 3 (Ebi3) is a β subunit within the IL-12 cytokine family that canonically binds to α subunits p19, p28, or p35 to form the heterodimeric cytokines IL-39, IL-27, and IL-35, respectively. In the last decade, the binding partners for Ebi3 have continued to expand to include IL-6 and the other IL-12 family β subunit p40, revealing the possibility that Ebi3 may be able to bind to other cytokines and have distinct functions. We first explored this possibility utilizing an in vivo mouse model of regulatory T cell-restricted deletions of the subunits composing the cytokine IL-35, p35, and Ebi3, and we observed a differential impact on CD8+ T cell inhibitory receptor expression despite comparable reduction in tumor growth.
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