Publications by authors named "C I Sayre"

Background: Within the neonatal intensive care unit (NICU), infants frequently receive packed red blood cell (PRBC) transfusions. Although medically necessary, potential negative long- and short-term outcomes exist following PRBC transfusions in very low birth-weight (VLBW) infants (<1500 g). Synthesis of the literature demonstrates that the use of a restrictive PRBC transfusion policy can lead to a decreased number of transfusions administered with no increase in long-term neurodevelopmental outcomes.

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  • Advanced neonatal resuscitation requires skilled intervention, but infrequent practice can lead to decreased competency among healthcare providers, potentially harming patient outcomes.
  • The project aimed to enhance the confidence and knowledge of advanced healthcare providers through simulation education based on the neonatal resuscitation program (NRP) curriculum across several NICUs.
  • Results showed a 7% improvement in knowledge scores post-simulation, with debriefing being the most effective method for increasing confidence and knowledge, particularly among neonatal nurse practitioners with more clinical experience.
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  • Amiloride is an FDA-approved diuretic used for treating hypertension and heart failure, but recent studies suggest it may help with anxiety.
  • Intranasal amiloride nasal spray could provide quick relief for anxiety disorders, although compounded versions lack the stability data of standard medications.
  • A study assessed the chemical stability of compounded amiloride nasal spray over 6 and 12 months, finding that it remains stable and compatible with preservatives based on various analytical methods.
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Topic: Early-life experiences, the transmission of health and disease within families, and the influence of cumulative risks as well as protective factors throughout life shape the trajectory of health, including mental health. Long-term health trajectories established early in life are influenced by biologic, social, and environmental factors. Negative trajectories may be more salient if exposures to adversity occur during critical developmental periods.

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Background: Training in speaking up skills for nursing professionals provides the groundwork for promoting a culture of curiosity and inquiry. At the foundation of speaking up is psychological safety for team members to disagree, offer alternative ideas, and ask questions.

Method: A large-scale training session, Finding Your Voice: Speaking Up & Listening Skills, was designed and delivered to 1,306 nurses at an academic medical center.

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