Publications by authors named "C I McCowan"
The role of biomarkers in risk-based early detection of lung cancer may enable screening to become cost effective and widely accessible. EarlyCDT-Lung is an example of such a blood-based autoantibody biomarker which may improve accessibility to Low dose Computed Tomography (LDCT) screening for those at highest risk. We randomized 12 208 individuals aged 50-75 at high risk of developing lung cancer to either the test or to standard clinical care.
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- The increasing prevalence of multiple long-term conditions (MLTCs) poses significant health challenges, leading to worse life expectancy and quality of life for affected individuals.
- An initiative named SysteMatic aims to create a co-designed action plan focused on equitable prevention and care for MLTCs, involving individuals with lived experiences, healthcare professionals, and industry partners in the UK.
- The Hub will analyze both personal experiences and large-scale health data to set specific innovation goals and foster system transformation over the next 3-7 years.
: : To provide contemporary data on cancer mortality rates within the context of incidence in the population with intellectual disabilities. : : Scotland's 2011 Census was used to identify adults with intellectual disabilities and controls with records linked to the Scottish Cancer Registry and death certificate data (March 2011-December 2019). The control cohort without intellectual disabilities and/or autism were used for indirect standardisation and calculation of crude incident rates/crude mortality rates, and age-sex standardised incident rate ratios/standardised mortality ratios (SIR/SMR), with 95% CIs.
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- * Using national Scottish data, the study finds that individuals with five or more conditions are significantly more likely to test negative for antibodies post-vaccination and have a much higher risk of COVID-19 hospitalization or death.
- * There's a clear link showing that lower antibody levels after vaccination are associated with increased risks of severe outcomes, including hospitalization and death, indicating the importance of monitoring antibody levels in vaccinated individuals.
Background: Subclinical hypothyroidism (SCH) is a biochemical thyroid disorder characterised by elevated levels of Thyroid Stimulating Hormone (TSH) together with normal levels of thyroid hormones. Evidence on the benefits of treatment is limited, resulting in persistent controversies relating to its clinical management.
Aim: This study describes the demographic and clinical characteristics of patients identified as having subclinical hypothyroidism in Wales between 2000 and 2021, the annual cumulative incidence during this period and the testing and treatment patterns associated with this disorder.