Publications by authors named "C I Lerner"
Aberrant activation of NLRP3 due to persistent tissue damage, misfolded proteins or crystal deposits has been linked to multiple chronic inflammatory disorders such as cryopyrin-associated periodic syndrome (CAPS), neurodegenerative diseases, gouty arthritis, and numerous others. Hence, there has been an increasing interest in NLRP3 inhibitors as therapeutics. A first generation of NLRP3 inhibitors bearing a sulfonylurea core such as MCC950 (developed by Pfizer) were discovered by phenotypic screening, however their mode of action was only elucidated later.
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- Cellular senescence is linked to aging and diseases, but measuring senescent cells is difficult due to a lack of specific markers and methods.
- The Fully-Automated Senescence Test (FAST) is introduced as an efficient, image-based technique to evaluate senescence in cultured cells by assessing key markers like SA-β-Gal activity, proliferation arrest, and cell morphology.
- FAST offers standardized, automated imaging and data analysis, minimizing false positives, and enables large-scale experiments in aging research by accurately quantifying senescence across various cell types.
Microgravity is associated with immunological dysfunction, though the mechanisms are poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear cells (PBMCs) exposed to short term (25 hours) simulated microgravity, we characterize altered genes and pathways at basal and stimulated states with a Toll-like Receptor-7/8 agonist. We validate single-cell analysis by RNA sequencing and super-resolution microscopy, and against data from the Inspiration-4 (I4) mission, JAXA (Cell-Free Epigenome) mission, Twins study, and spleens from mice on the International Space Station.
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- The study aimed to compare the effectiveness of electronic health record (EHR)-based portal reminders and text message reminders in increasing influenza vaccination rates in a health system.
- Conducted as a randomized clinical trial from September 2022 to April 2023 at UCLA, the trial included over 262,000 patients across different reminder strategies.
- Results showed differences in vaccination rates based on the type of reminder sent, indicating that tailored reminders could enhance public health efforts to improve flu vaccination participation.
Purpose: Adults' comments on patient experience surveys explain variation in provider ratings, with negative comments providing more actionable information than positive comments. We investigate if narrative comments on the Consumer Assessment of Healthcare Providers and Systems (CAHPS®) survey of inpatient pediatric care (Child HCAHPS) account for global perceptions of the hospital beyond that explained by reports about specific aspects of care.
Methods: We analyzed 545 comments from 927 Child HCAHPS surveys completed by parents and guardians of hospitalized children with at least a 24-h hospital stay from July 2017 to December 2020 at an urban children's hospital.