Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme.

The Cancer Programme of the 100,000 Genomes Project was an initiative to provide whole-genome sequencing (WGS) for patients with cancer, evaluating opportunities for precision cancer care within the UK National Healthcare System (NHS). Genomics England, alongside NHS England, analyzed WGS data from 13,880 solid tumors spanning 33 cancer types, integrating genomic data with real-world treatment and outcome data, within a secure Research Environment. Incidence of somatic mutations in genes recommended for standard-of-care testing varied across cancer types.

KNOWLEDGE OF MPOX AMONG PRIMARY HEALTH CARE (PHC) WORKERS IN JOS NORTH LOCAL GOVERNMENT AREA, PLATEAU STATE. NIGERIA.

Introduction: Mpox (MPX) is a viral zoonotic (a virus transmitted to humans from animals) disease caused by Mpox virus currently spreading across the world. Primary healthcare workers are fundamental in the provision of healthcare at the grassroots level. They are the front-line health managers who are expected to meet the needs of their community and prevent the spread of Mpox in Nigeria.

KNOWLEDGE, AND ACCEPTANCE OF THE COVID-19 VACCINE AMONG WOMEN ATTENDING ANTENATAL AT PRIMARY HEALTHCARE CENTRES, JOS-PLATEAU STATE; NIGEIRA.

Introduction: COVID-19 Vaccination has been met with a variation in acceptability for various reasons, ranging from spiritual to physical perception of the vaccines, false information, and lack of information. Adequate knowledge and positivity will lead to high acceptance and willingness to take the vaccine. Acceptance of the vaccine by the general public and healthcare workers appears to play a major role in controlling the pandemic.

Actin-dependent recruitment of AGO2 to the zonula adherens.

Adherens junctions are cadherin-based structures critical for cellular architecture. E-cadherin junctions in mature epithelial cell monolayers tether to an apical actomyosin ring to form the zonula adherens (ZA). We have previously shown that the adherens junction protein PLEKHA7 associates with and regulates the function of the core RNA interference (RNAi) component AGO2 specifically at the ZA.