Publications by authors named "C I Bloom"
Importance: Elevated body mass index (BMI) and type 2 diabetes are prevalent in asthma and are associated with an increase in the risk of asthma attacks. In experimental studies, the diabetes medications metformin and glucagon-like peptide-1 receptor agonists (GLP-1RA) have mitigated airway inflammation, hyperresponsiveness, and remodeling. However, epidemiological evidence is limited.
View Article and Find Full Text PDFBackground: Guidelines advise minimizing asthma exacerbation risk, which is achieved partially through good clinical practice activities, including scheduled asthma reviews, inhaler technique checks, and asthma management plans. We assessed how frequently these activities are provided and how effective they are in clinical practice.
Research Question: Do guideline-recommended activities such as asthma reviews, inhaler technique checks, and asthma management plans prevent asthma exacerbations?
Study Design And Methods: This retrospective chart review used United Kingdom primary care medical records between 2004 and 2021, linked to hospital records.
Surgery and postoperative definitive radiotherapy for management of canine soft tissue sarcoma: a multi-institutional retrospective study of 272 dogs (2010-2020).
J Am Vet Med Assoc
September 2024
Objective: To report local progression and survival in dogs following surgery and postoperative definitive radiotherapy (dRT) for management of soft tissue sarcoma (STS) and to evaluate risk factors for local progression and survival.
Methods: Records were retrospectively reviewed at 9 referral hospitals for dogs managed with postoperative dRT between January 1, 2010, and January 1, 2020, following surgery for STS. Data related to presentation, surgery, dRT, systemic therapy, and outcome were abstracted.
Sex-based differences in candidacy for transcatheter tricuspid valve intervention.
Catheter Cardiovasc Interv
October 2024
Article Synopsis
- - Women have a higher prevalence of tricuspid regurgitation (TR) and tend to present with more advanced stages of the condition compared to men, leading to the exploration of sex-based differences in eligibility for transcatheter tricuspid valve interventions (TTVI).
- - A study of 569 patients revealed that while men exhibited more left ventricular dysfunction and heart failure signs, women were more likely to experience isolated TR and TR linked to severe pulmonary hypertension.
- - Despite differences in presenting conditions, the majority of patients were not eligible for TTVI, and sex did not significantly impact eligibility for the procedure.