Publications by authors named "C Hunt"

Regional and global environmental challenges have become increasingly complex and require broader solutions than a single discipline can provide. Although there is a growing need for interdisciplinary research, many graduate education programs still train students within the confines of a particular discipline or specialty. The Ridge 2 Reef research traineeship program at the University of California, Irvine, aimed to provide transferable and interdisciplinary skill training to prepare graduate students from different disciplines to address current and future environmental challenges.

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Background: Complex Regional Pain Syndrome (CRPS) is a condition that causes persistent and debilitating pain. It is often associated with physical injury but can also occur without identifiable trauma or ongoing injury. There are no published guidelines for CRPS treatment in the pediatric population, but interdisciplinary care, medication, and physical therapy are common approaches.

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To date, sparse attention has been paid to the importance of the "lived experience" of participants and their caregivers in pediatric gene therapy (GT) trials for rare genetic neurological disorders. Pediatric GT studies differ meaningfully from adult GT studies as the decision to participate involves a dyad: the child participant and their caregiver(s). As a multistakeholder group of authors, we are a diverse group with expert perspectives on the social, emotional, physical, and logistical burdens/benefits of trial participation and the myriad ways they affect pediatric GT research.

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Article Synopsis
  • GH29A α-l-fucosidases are enzymes that help break down specific sugars in glycoconjugates and can also be used to create human milk oligosaccharides (HMOs) through a process called transglycosylation.
  • Researchers used bioinformatics tools and phylogenetic clustering to identify and analyze new microbial GH29A α-l-fucosidases from an underexplored group, as well as previously known enzymes, to determine their biochemical properties and behavior under different conditions.
  • The study found that transglycosylation of certain substrates was most effective at neutral to alkaline pH levels and revealed new structural insights into how these enzymes function, particularly regarding regioselectivity in product formation.
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Rosai-Dorfman Disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare non-Langerhans cell histiocytic neoplasm. Although the disease classically presents as massive painless lymphadenopathy in young adults, RDD can also involve the central nervous system in some patients. CNS lesions, can cause headaches, neurologic deficits, and even neurologic deficits.

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