Publications by authors named "C Hultman"
Background: While the United States has the highest incarceration rate worldwide, at nearly 1% of the adult population (more than 2 million people), insights regarding health disparities in this population remain limited. This retrospective cohort study represents the largest national database analysis of incarcerated trauma patients to date and investigates whether incarceration status is an independent risk factor for poor outcomes after trauma for US adults.
Methods: We analyzed data from the National Trauma Data Bank from 2017 to 2018.
Article Synopsis
- Scientists found that anesthesia during childbirth can change the DNA tags in newborn babies' blood, which is called the methylome.
- They noticed that different types of anesthesia, like laughing gas and pudendal block, affected different blood cells in babies.
- This study is important because it helps us understand how pain relief given to moms during delivery might have an impact on their newborns' biology.
Article Synopsis
- Schizophrenia and bipolar disorder are heritable psychiatric conditions; this study aims to explore how genetic factors, specifically polygenic risk scores (PRS), influence psychosis among twins.* -
- Using data from the Schizophrenia and Bipolar Twin Study and the Swedish Twin Registry, researchers analyzed twin pairs to see if those with higher PRS had increased likelihood of psychosis.* -
- The final analysis included over 300 twin pairs, assessing psychosis through clinical interviews, with the goal of determining the heritability of psychosis and understanding genetic overlap between the two disorders.*
Article Synopsis
- Monozygotic (MZ) twins, typically considered genetically identical, actually can have differing DNA variants due to early post-zygotic events, which may relate to differences in disease manifestation.
- In a study involving whole genome sequencing of 17 pairs of MZ twins discordant for psychotic disorders, researchers found rare genetic variants unique to affected individuals, including specific genes linked to schizophrenia and bipolar disorder.
- The research identified significant genetic variations, such as deleterious missense variants and rare genic copy number variants (CNVs), suggesting a potential link to the disorders, and emphasizes the need for further investigation in this area.
Finding a perfect epidermal transplant remains a holy grail of burn surgery. The epidermis is a site of stem cells that allows for epithelial regeneration. The use of cultured epithelial autografts (CEA) for the treatment of major burns was first reported in 1981.
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