Publications by authors named "C Huch"
Article Synopsis
- Seroprevalence studies are essential for monitoring diseases, but the presence of multiple flaviviruses and vaccination efforts complicate testing for dengue virus, a key focus of this research.
- A study involving 770 children in Cambodia assessed the performance of a common dengue serology test, revealing lower specificity than expected and highlighting that many false positives had immunity to other flaviviruses.
- The findings suggest increasing the cut point for the dengue IgG test can improve accuracy, and there is a need for public health awareness regarding the presence of West Nile virus in the region.
Seroprevalence studies are the gold standard for disease surveillance, and serology was used to determine eligibility for the first licensed dengue vaccine. However, expanding flavivirus endemicity, co-circulation, and vaccination complicate serology results. Among 713 healthy Cambodian children, a commonly used indirect dengue virus IgG ELISA (PanBio) had a lower specificity than previously reported (94% vs.
View Article and Find Full Text PDFGlobal dengue incidence has increased dramatically over the past few decades from approximately 500 000 reported cases in 2000 to over 5 million in 2019. This trend has been attributed to population growth in endemic areas, rapid unplanned urbanization, increasing global connectivity, and climate change expanding the geographic range of the . mosquito, among other factors.
View Article and Find Full Text PDFObjective: Data from 19 years of national dengue surveillance in Cambodia (2002-2020) were analyzed to describe trends in dengue case characteristics and incidence.
Methods: Generalized additive models were fitted to dengue case incidence and characteristics (mean age, case phenotype, fatality) over time. Dengue incidence in a pediatric cohort study (2018-2020) was compared to national data during the same period to evaluate disease under-estimation by national surveillance.
SignificanceMetagenomic pathogen sequencing offers an unbiased approach to characterizing febrile illness. In resource-scarce settings with high biodiversity, it is critical to identify disease-causing pathogens in order to understand burden and to prioritize efforts for control. Here, metagenomic next-generation sequencing (mNGS) characterization of the pathogen landscape in Cambodia revealed diverse vector-borne and zoonotic pathogens irrespective of age and gender as risk factors.
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