French validation of the Multiple Sclerosis Work Difficulties Questionnaire (MSWDQ-23) with determination of cutoff scores: A valuable tool in clinical practice.

Work difficulties are a primary issue of multiple sclerosis (MS). This is because disease onset usually occurs during a time when establishing a career and employment is of paramount importance. The MSWDQ-23 (Multiple Sclerosis Work Difficulties Questionnaire) was developed to assess work difficulties in MS.

Emotion perception and online awareness following alcohol-intoxication: investigating possible deficits using the complex audio visual emotion assessment task.

Rationale: Alcohol-intoxication is implicated in negative social behaviours, however the mechanisms underlying this relationship are poorly understood. Impaired emotion perception following alcohol consumption may partially account for this link, however limited methodology in prior studies undermines the efficacy of this explanation.

Objectives: The current study investigated the effect of acute moderate-dose alcohol-intoxication on basic and compound emotion perception abilities using contextualised video vignettes.

Barriers for work in people with multiple sclerosis: a Norwegian cultural adaptation and validation of the short version of the multiple sclerosis work difficulties questionnaire.

Background And Purpose: Multiple sclerosis (MS) is associated with high rates of unemployment, and barriers for work are essential to identify in the regular follow-up of these people. The current study aimed to culturally adapt and evaluate the psychometric properties of the Norwegian version of the Multiple Sclerosis Work Difficulties Questionnaire-23 (MSWDQ-23).

Methods: Following backward and forward translation, the Norwegian version of the MSWDQ-23 (MSWDQ-23NV) was completed by 229 people with multiple sclerosis (MS).

Impact of sleep quality on health-related quality of life domains and the mediating effects of symptoms in people with multiple sclerosis.

Purpose: Many people living with multiple sclerosis (PwMS) experience poor sleep, which is associated with diminished overall health-related quality of life (HRQoL). We quantified associations between sleep quality and HRQoL domains and examined the extent to which other MS symptoms could account for these associations.

Methods: In this cross-sectional survey of 1,717 Australians with MS, we used Assessment of Quality of Life (AQoL) 8D and Pittsburgh Sleep Quality Index (PSQI) to assess HRQoL and sleep quality, respectively.

mRNA-delivery of IDO1 suppresses T cell-mediated autoimmunity.

Indoleamine-2,3-dioxygenase (IDO)1 degrades tryptophan, obtained through dietary intake, into immunoregulatory metabolites of the kynurenine pathway. Deficiency or blockade of IDO1 results in the enhancement of autoimmune severity in rodent models and increased susceptibility to developing autoimmunity in humans. Despite this, therapeutic modalities that leverage IDO1 for the treatment of autoimmunity remain limited.