Genomic insights into drug resistance and virulence determinants in rare pyomelanin-producing clinical isolates of Acinetobacter baumannii.

Purpose: Clinical isolates of multi-drug resistant Acinetobacter baumannii are a major cause of nosocomial infections, often attributed to the highly adaptable genome that helps it to thrive under environmental selection pressure. Here, we aim to provide genotypic-based surveys and comparative whole genome sequencing (WGS) analysis to explore the genomics of the rare pyomelanin-forming clinical isolates of A. baumannii from India.

ABC score is a better predictor for 30-day mortality in upper gastrointestinal bleeding: A prospective single-center study.

Background: Acute upper gastrointestinal bleeding (UGIB) still has a mortality rate of about 10%. Several pre-endoscopy scoring systems have been developed to predict the outcome, but none accurately predict mortality. The present study was aimed at comparing the new ABC score (age, blood tests and comorbidities) with other pre-existing scoring systems to predict mortality.

Comparative evaluation of the influence of the palatal root length on the efficacy of maxillary buccal infiltration by open and closed mouth technique: a randomized control trial.

Background: Maxillary molars are commonly anesthetized via buccal infiltration. A patient's mouth opening during maxillary buccal infiltration can influence dental treatment. Hence, this study aimed to evaluate and compare the influence of palatal root length on the efficacy of 2% lidocaine in 1:80000 adrenaline for maxillary buccal infiltration (MBI) between the open- and closed-mouth techniques.

Combined effects of fluoroquinolone antibiotic enrofloxacin and rising sea temperatures on the health of the Mediterranean mussel (Mytilus galloprovincialis): Exploring physiological, biochemical, and energetic balance dynamics.

Human activity exposes organisms in marine ecosystems to numerous stressors, including rising seawater temperatures and antibiotic contamination. The present study investigated the impacts of environmentally relevant concentrations of the fluoroquinolone (FQ) antibiotic enrofloxacin (ENR), specifically 5 and 500 ng/L, in Mytilus galloprovincialis under ambient (20 °C) and predicted warming (25 °C) conditions after 14 days of exposure, followed by a 14-day recovery period in the absence of ENR. The chemical analyses revealed significant variability in bioaccumulation in mussel tissues.