Publications by authors named "C Hock"
NI006 (aka ALXN2220) is a therapeutic antibody candidate in phase III clinical development for the depletion of amyloid transthyretin (ATTR) in patients with ATTR cardiomyopathy, an infiltrative cardiomyopathy leading to increased left ventricular wall thickness (LVWT). The mode-of-action consists in removal of disease-causing amyloid accumulations by activating phagocytic immune cells, a mechanism without precedent in cardiology. To select a safe and potentially efficacious dose range and treatment duration for a combined first-in-human and proof-of-concept clinical phase Ib study, we developed a mechanistic pharmacokinetic and pharmacodynamic (PK/PD) model that can predict NI006 exposure, its effects on cardiac amyloid load and on LWVT, which is a predictor of heart failure in this disease.
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- This study investigates the metabolic and bioenergetic changes in the spinal cord of a transgenic mouse model of Parkinson's disease (M83) that overexpresses a mutated form of alpha-synuclein, comparing it to non-transgenic mice.!* -
- Using advanced imaging techniques, the researchers found that the M83 mice had lower oxygen saturation levels in their spinal cords, but there were no significant changes in spinal cord volume or vascular organization despite the presence of phosphorylated alpha-synuclein.!* -
- The study highlights the development of deep learning tools for analyzing spinal cord MRI data, and underscores the complexity of Parkinson's disease by showing reduced oxygen levels without related structural changes in the spinal cord.!
Article Synopsis
- * The study involved 140 healthy older adults and 49 with mild cognitive impairment, using techniques like APOE genotyping and MRI to measure GSH levels in the brain.
- * Findings indicated that higher GSH levels are more common in females, while older age and the presence of the APOE4 genotype are associated with increased amyloid levels, highlighting sex-specific differences in GSH levels among older adults.
Introduction: We investigated the interactive associations between amyloid and hypertension on the entorhinal cortex (EC) tau and atrophy and the role of cerebral blood flow (CBF) as a shared mechanism by which amyloid and hypertension contribute to EC tau and regional white matter hyperintensities (WMHs).
Methods: We analyzed data from older adults without dementia participating in the Add-Tau study (NCT02958670, n = 138) or Alzheimer's Disease Neuroimaging Initiative (ADNI) (n = 523) who had available amyloid-positron emission tomography (PET), tau-PET, fluid-attenuated inversion recovery (FLAIR), and T1-weighted magnetic resonance imaging (MRI). A subsample in both cohorts had available arterial spin labeling (ASL) MRI (Add-Tau: n = 78; ADNI: n = 89).
Owing to its roles in cellular signal transduction, protein phosphorylation plays critical roles in myriad cell processes. That said, detecting and quantifying protein phosphorylation has remained a challenge. We describe the use of a novel mass spectrometer (Orbitrap Astral) coupled with data-independent acquisition (DIA) to achieve rapid and deep analysis of human and mouse phosphoproteomes.
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