Publications by authors named "C Hobbs"
We assessed severe acute respiratory syndrome coronavirus 2 seroprevalence on residual blood samples for pediatric COVID-19 surveillance: 2263 samples were collected during routine outpatient visits (<18 years, April 2020-August 2021). Seroprevalence increased over time, coinciding with or preceding virus circulation in the community and with or preceding pediatric severe COVID-19 hospitalization peaks. Residual blood sample seroprevalence may be a useful surveillance tool in future outbreaks.
View Article and Find Full Text PDFPigmented villonodular synovitis (PVNS) is an uncommon hyperproliferative disease of the synovium presenting either as localized or a more aggressive diffuse form. Its occurrence following total knee arthroplasty (TKA) is rare, and its presentation alongside patellar clunk syndrome (PCS) has not been previously reported. We present a case of a 64-year-old female patient diagnosed with diffuse PVNS (D-PVNS) two and half years following TKA, co-occurring with PCS.
View Article and Find Full Text PDFPolycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants that originate from the incomplete combustion of organic materials. We investigated the clastogenicity and mutagenicity of benzo[]fluoranthene (BbF), one of 16 priority PAHs, in MutaMouse males after a 28 day oral exposure. BbF causes robust dose-dependent increases in micronucleus frequency in peripheral blood, indicative of chromosome damage.
View Article and Find Full Text PDFArticle Synopsis
- Cyclodextrins and their derivatives are widely used in pharmaceuticals, cosmetics, and food due to their unique properties.
- Monosubstituted cyclodextrin derivatives are easier to synthesize, while di-substituted derivatives face challenges like low yields and difficult purification.
- This study introduces a new method for synthesizing di-substituted cyclodextrin derivatives that achieves a 33% yield without requiring chromatography, simplifying the process for larger applications.
Purpose: The etiopathogenesis of coronal nonsyndromic craniosynostosis (cNCS), a congenital condition defined by premature fusion of 1 or both coronal sutures, remains largely unknown.
Methods: We conducted the largest genome-wide association study of cNCS followed by replication, fine mapping, and functional validation of the most significant region using zebrafish animal model.
Results: Genome-wide association study identified 6 independent genome-wide-significant risk alleles, 4 on chromosome 7q21.