Vascular Function and Distribution of Adiponectin Isomers during Puberty in Children and Adolescents with Obesity.

Introduction: Youth with obesity have abnormal vascular function that relates to the anti-atherogenic adipose-derived hormone, adiponectin. The distribution of adiponectin isomers changes during normal puberty, but there are no data in relation to vascular function. We aimed to evaluate vascular function, adiponectin, and its isomers longitudinally in peri-pubertal youth with obesity and controls.

[Presacral lesion at the rima ani].

A 26-year-old woman presented with a painful bulge at the rima ani. The tumor was located in the presacral region. Histological examination revealed a well-circumscribed biphenotypical tumor with papillary configured myxoid areas and strongly sclerosing regions.

Lack of evidence for progression of atherosclerosis during puberty in type 1 diabetes.

Objectives: Children with type 1 diabetes have early changes in vascular structure with increased aortic intima-media thickness (aIMT) or carotid IMT (cIMT). aIMT may be an earlier, more sensitive marker; however, longitudinal data in type 1 diabetes are lacking. This study will aim to evaluate changes in vascular structure (aIMT and cIMT) over 2 yr during puberty in children with type 1 diabetes and compare them with those in healthy children.

Adolescents with congenital adrenal hyperplasia because of 21-hydroxylase deficiency have vascular dysfunction.

Context: Patients with congenital adrenal hyperplasia (CAH) because of 21-hydroxylase deficiency have multiple vascular risk factors. Young adults with CAH have increased intima media thickness, but there have been no studies of vascular function and structure in children with CAH.

Objective: To establish whether children with CAH have reduced vascular function and increased carotid intima media thickness (cIMT) when compared to healthy and obese children.

Aortic intima media thickness is an early marker of atherosclerosis in children with type 1 diabetes mellitus.

Objective: To compare aortic intima media thickness (aIMT) to carotid intima media thickness (cIMT) as a marker of early atherosclerosis in children with type 1 diabetes mellitus and to examine the associations of aIMT to known cardiovascular risk factors.

Study Design: 66 children with type 1 diabetes mellitus (age, 14.1 +/- 2.